Struvite Stones Antibiotic Study

Status Recruiting

Clinical Trial Summary

The aim of this research is to determine an effective antibiotic regimen following definitive surgical therapy of kidney stones caused by bacterial infection (struvite stones).

Clinical Trial Description

Struvite stones or infection stones are a subset of kidney stones that are related to bacterial infection. They only make up 15% of all kidney stones, but account for a much higher percentage of mortality (up to 67%) compared to other stones-due to the infectious component. Treatment is to ensure 100% eradication of the stone with surgery followed by antibiotics to eliminate the infection. Failure to eliminate the bacteria results in the stone growing back quickly. It is unknown how long antibiotics should be administered immediately after surgery-some urologists give 2-4 weeks while others give 2-3 months. We seek to randomize patients to receive 2 weeks of antibiotics or 3 months of antibiotics after surgery to remove all the kidney stones. We will see patients at 3, 6, and 12 months with x-rays and to test their urine for bacterial infections. This is a multi-centre study with participating 12 sites across North America. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02375295
Study type	Interventional
Source	University of British Columbia
Contact	Olga Arsovska
Phone	6048754111
Email	olga.arsovska@ubc.ca
Status	Recruiting
Phase	Phase 4
Start date	March 2015
Completion date	December 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02547805` - Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days	Phase 2
Completed	`NCT02579161` - Trial of Randomized Antibiotic Administration in Percutaneous Nephrolithotomy	Phase 3
Completed	`NCT01187745` - Study to Look for Artifact on Computed Tomography (CT) Representing Kidney Stones	N/A
Withdrawn	`NCT00875823` - International Registry for Primary Hyperoxaluria	N/A
Completed	`NCT05519150` - Donors With Nephrolithiasis at the Time of Transplant Evaluation (DONATE). Long Term Follow-up.
Recruiting	`NCT02522689` - Comparison of Ultra-mini PCNL and Micro PCNL	N/A
Recruiting	`NCT01514032` - Extracorporal Shockwave Lithotripsy Versus Retrograde Intrarenal Surgery for the Treatment of Kidney Stones	N/A
Completed	`NCT00765128` - Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy	Phase 4
Completed	`NCT00873054` - Percutaneous Nephrolithotomy Versus Extracorporeal Shock Wave Lithotripsy	N/A
Withdrawn	`NCT00583258` - A Randomized Study of Whether Alfuzosin(Xatral) Helps in the Passage of Kidney Stones	N/A
Active, not recruiting	`NCT03630926` - Evaluation of the NV-VPAC1 Prostate Cancer (PCa) Urine Diagnostic Test in Subjects With Biopsy-confirmed Prostate Cancer, Benign Prostatic Hypertrophy, or Bladder/Kidney Stones.
Not yet recruiting	`NCT02214836` - Ultrasound Imaging of Kidney Stones and Lithotripsy	N/A
Completed	`NCT03095885` - A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria	N/A
Completed	`NCT01088555` - Effect of Sodium Thiosulfate on Urine Chemistries of Hypercalciuric Stone Formers	N/A
Completed	`NCT01330940` - Effect of Diet Orange Soda on Urinary Lithogenicity	N/A
Recruiting	`NCT00489723` - Is There is a Role of Prophylactic Therapy With Tamsulosin Before Extracorporeal Shock Wave Lithotripsy to Avoid Development of Steinstrasse ?	N/A
Recruiting	`NCT05417568` - Oxalate-Driven Host Responses in Kidney Stone Disease	N/A
Enrolling by invitation	`NCT02408211` - Preoperative Antibiotic PNL Study	Phase 4
Withdrawn	`NCT01560091` - Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy	Phase 3
Completed	`NCT00857090` - Pharmacokinetic, Safety and Efficacy Study of OMS201 in Subjects Undergoing Retrograde Ureteroscopic Removal of Upper Urinary Tract Stones	Phase 1/Phase 2