A Novel Method for Retrograde Intrarenal Surgery (RIRS)

Status Not yet recruiting

Clinical Trial Summary

In this prospective randomised controlled study, investigators aims to evaluate the effect of 80 mg gentamicin added to 3 liters of irrigation fluid on stone free rate, intraoperative and postoperative complications during RIRS for kidney stones.

Clinical Trial Description

Current advances in endoscopic technology for the upper urinary tract have expanded the diagnosis and treatment options for kidney stones. Retrograde intrarenal surgery (RIRS), defined as the use of effective lithotripters such as flexible ureteroscopes (fURSs) and holmium:yttrium aluminum garnet (holmium:YAG) lasers for intrarenal pelvic diseases, is a safe and effective, versatile and minimally invasive procedure for the kidney. . Current guidelines for the treatment of kidney stones recommend RIRS first for stones <2 cm. and RIRS as one of the first two options for stones >2 cm.. In studies dealing with kidney stones larger than 2 cm, the RIRS showed a cumulative stone-free success of 91%, but a complication rate of 8.6%. Of these, 44% were found to be ≥ Clavien 3 complications. In kidney stone endourological treatments, stone culture was found to be more effective in predicting complications than midstream urine culture. Even if the preoperative midstream urine culture is sterile, complication rates increase if there is bacterial growth in the stone culture in kidney stone surgery. Therefore, although complication rates are generally low, several concerns have arisen. In our study, the investigators aims to evaluate the effect of 80 mg gentamicin added to 3 liters of irrigation fluid on stone free rate and complications during RIRS for kidney stones. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05202158
Study type	Interventional
Source	Ankara Training and Research Hospital
Contact	Ali Kaan Yildiz
Phone	+90 554 773 16 96
Email	[email protected]
Status	Not yet recruiting
Phase	N/A
Start date	February 15, 2022
Completion date	July 1, 2022

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04495699` - Asymptomatic Renal Calculi in Recurrent Urinary Tract Infections
Recruiting	`NCT04559321` - Holmium Vs Trilogy Kidney Stones GUY's 1-2	Phase 3
Active, not recruiting	`NCT04332861` - Evaluation of Infection in Obstructing Urolithiasis
Recruiting	`NCT03877276` - Dietary Oxalate and Immune Cell Function	N/A
Not yet recruiting	`NCT05022537` - Clinical Outcomes of Percutaneous Nephrolithotomy Following Retrograde Percutaneous Nephrostomy Access Using Novel Device in Comparison to Antegrade Access	N/A
Completed	`NCT03872843` - Opioid Free Management After Ureteroscopy	Phase 4
Recruiting	`NCT04333745` - Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers	N/A
Recruiting	`NCT04389853` - Mini-PNCL vs fURS in Management of Nephrolithiasis	N/A
Not yet recruiting	`NCT05081960` - Evaluating the Vitamin K2 Status of Calcium-based Stone Formers
Not yet recruiting	`NCT04605055` - The Interplay Between Oxalate, Immunity and Infection	N/A
Not yet recruiting	`NCT04545528` - The Impact of Nutritional Service in the Stone Clinic on the Patient Urine Collection Results
Recruiting	`NCT03281928` - Effect of Dietary Sodium and Potassium Citrate on Renal Mineral Handling	N/A
Recruiting	`NCT04835922` - Comparison of Efficacy of Intercostal Nerve Block vs Peritract Infiltration With 0.25% Bupivacaine in PCNL	N/A
Recruiting	`NCT03257306` - Magnetic Ureteral Stent Symptoms - a Comparison to Standard Ureteral Stent as Perceived By the Patient (MAGUSS)	N/A
Not yet recruiting	`NCT04997668` - Clinical Outcomes and Healthcare Economics of SOLTIVE Compared to Ho:YAG Laser in Urolithiasis	N/A
Not yet recruiting	`NCT04606758` - Fluoroscopic Guided vs US-guided Percutaneous Nephrolithotripsy for the Treatment of Stone Disease	N/A
Withdrawn	`NCT01980004` - Potassium Citrate Supplementation vs. Dietary Counseling	Phase 2
Completed	`NCT00289120` - Effect of Cola on Urinary Stone Risk Factors	N/A
Recruiting	`NCT04603898` - Oxalate Formation From Ascorbic Acid	N/A
Recruiting	`NCT04243772` - Metabolic Risk Factors and Stones Composition in Adult Kidney Stone Formers