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Dietary Oxalate and Immune Cell Function

Kidney Stone Clinical Trial

Official title:
Dietary Oxalate and Immune Cell Function

Clinical Trial Summary

The purpose of this study is to evaluate mitochondrial function in white blood cells and platelets from healthy individuals following dietary oxalate intake.

Clinical Trial Description

Inflammation and dietary oxalate have been shown to play an important role in the development of kidney stones. Oxalate is a small molecule found in plants and plant-derived food. Individuals that have high oxalate intake have an increased risk of developing kidney stones. The co-investigators have previously shown that healthy subjects that consume dietary oxalate have increased plasma and urine oxalate. White blood cells are essential for the immune response and rely on the mitochondria to carry out important cell functions. The Principal Investigator's current research shows that patients with calcium oxalate kidney stones have decreased mitochondrial function in their immune cells. Using the expertise of the investigators, this study will test whether oxalate has a direct effect on mitochondrial function in immune cells from healthy subjects. This information could help us understand the role of oxalate on the immune system during kidney stone pathogenesis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03877276
Study type Interventional
Source University of Alabama at Birmingham
Contact
Status Active, not recruiting
Phase N/A
Start date July 21, 2016
Completion date December 1, 2024
View Details
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