Non-small Cell Lung Cancer Clinical Trial
Official title:
A Phase l/ll, Open Label, Dose-escalation Study of Varlilumab (CDX-1127) in Combination With Atezolizumab (MPDL3280A, Anti-PD-L1) in Patients With Advanced Cancer
This is a study to determine the clinical benefit (how well the drug works), safety and
tolerability of combining varlilumab and atezolizumab. Phase l of the study will enroll
patients with a number of tumor types; Phase ll will enroll only patients with renal cell
carcinoma (RCC).*
*Note: This Study was terminated prior to initiation of Phase II
Varlilumab is a fully human monoclonal antibody that binds to a molecule called CD27 found on
certain immune cells and may act to promote anti-tumor effects.
Atezolizumab is an engineered anti-PD-L1 antibody.
This study will evaluate the safety, tolerability and efficacy of the anti-CD27 antibody
varlilumab in combination with atezolizumab.
Eligible patients that enroll in the dose escalation portion of the study will be assigned to
one of three dose levels of varlilumab in combination with 1200 mg of atezolizumab. The first
phase of the study will enroll up to 18 patients and test the safety profile of the
combination of varlilumab and atezolizumab in patients with various tumor types and determine
which dose of varlilumab will be studied in Phase ll* of the study which will enroll only
patients with RCC.
*Note: This Study was terminated prior to initiation of Phase II.
All patients enrolled in the study will be closely monitored to determine if there is a
response to the treatment as well as for any side effects that may occur.
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