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Metformin Versus Vildagliptin in Reducing Risk of Metabolic Syndrome Complications Progression

Metabolic Syndrome Clinical Trial

Official title:
Comparative Effecacy of Metformin and Vildagliptin on Cardiometabolic Risk Factors, Metabolic Syndrome, and Diabetic Nephropathy Progression

Clinical Trial Summary

Several crosssectional and prospective studies have shown that metabolic syndrome and its related components are associated with both prevalent and incident CKD .

Although the mechanisms for these cardiovascular benefits of Metformin and vildagliptin remain unclear, they extend well beyond glycemic lowering, and therefore are probably best considered diverse "cardiometabolic" pharmaceuticals rather than simply type 2 diabetes drugs.

Metformin and vildagliptin have known vasculoprotective actions, but the value of these drugs on drug-naïve diabetic patients during 24 week use warrants investigation. The investigator's purpose was to observe their effects on weight control, Cardiometabolic Risk Factors, Metabolic Syndrome risk, and diabetic nephrooathy Progression.

Clinical Trial Description

the current study is investigating the relation betweeneach componant of metabolic syndrome and kidney injury incidence or prevalence, and the mechanism of its occurence. the kidney protective effect of metformin and vildagliptin and the mechanism of this action whether it is related to their glucose lowering mechanism or not is also one of the important points to be investigated in the study ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04485845
Study type Interventional
Source Cairo University
Contact Dalia Zaafar, PhD
Phone 00201117922833
Email dalia.zaffar@pharm.mti.edu.eg
Status Recruiting
Phase Phase 4
Start date November 1, 2019
Completion date September 30, 2020
View Details
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