Metabolic Syndrome Clinical Trial
Official title:
Comparative Effecacy of Metformin and Vildagliptin on Cardiometabolic Risk Factors, Metabolic Syndrome, and Diabetic Nephropathy Progression
Several crosssectional and prospective studies have shown that metabolic syndrome and its
related components are associated with both prevalent and incident CKD .
Although the mechanisms for these cardiovascular benefits of Metformin and vildagliptin
remain unclear, they extend well beyond glycemic lowering, and therefore are probably best
considered diverse "cardiometabolic" pharmaceuticals rather than simply type 2 diabetes
drugs.
Metformin and vildagliptin have known vasculoprotective actions, but the value of these drugs
on drug-naïve diabetic patients during 24 week use warrants investigation. The investigator's
purpose was to observe their effects on weight control, Cardiometabolic Risk Factors,
Metabolic Syndrome risk, and diabetic nephrooathy Progression.
the current study is investigating the relation betweeneach componant of metabolic syndrome and kidney injury incidence or prevalence, and the mechanism of its occurence. the kidney protective effect of metformin and vildagliptin and the mechanism of this action whether it is related to their glucose lowering mechanism or not is also one of the important points to be investigated in the study ;
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