Cancer Clinical Trial
Official title:
Electronic Medical Records and Genomics (eMERGE) Phase III
The Electronic Medical Records and Genomics (eMERGE) Network is in its third phase and during this time is enrolling and sequencing 25,000 individuals on a custom sequencing panel of clinically relevant, actionable genes. The genetic results will be returned to participants and outcomes tracked through the electronic health records.
The Electronic Medical Records and Genomics (eMERGE) Network is a National Human Genome
Research Institute (NHGRI)-funded consortium tasked with developing methods and best
practices for utilization of the electronic medical record (EMR) as a tool for genomic
research. Phase III is focused on returning actionable gene variants to patients and
measuring clinical outcomes. Ultimately, eMERGE hopes its efforts will result in improvements
in health care, through safer and more effective prescription methodology, augmentation of
primary and secondary prevention strategies, and enhanced understanding of the biology of
disease.
eMERGE is composed of 10 clinical sites [ Childrens Hospital of Pennsylvania (CHOP);
Cincinnati Children's Medical Center (CCHMC); Columbia University; Geisinger; Kaiser
Permanente Washington with Washington University and the Fred Hutchinson Cancer Research
Center; Harvard University; Mayo Clinic; Meharry Medical College; Northwestern University;
Vanderbilt University Medical center (VUMC)], one non clinical site: Marshfield Clinic, two
sequencing centers [Baylor college of Medicine; Partners Healthcare with Broad Institute], a
Coordinating Center (VUMC), and the NHGRI. More information on the eMERGE Network can be
found at www.gwas.org.
Each sites' research study is tailored to their specific interests. An eMERGE specific
sequencing panel was designed and ran on participants covering 109 genes and 1551 Single
Nucleotide Variants (SNVs), of which 68 genes and 14 SNVs are clinically actionable and are
being returned to patients.
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