Obesity Clinical Trial
Official title:
Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
The very low carbohydrates diet (VLCKD) induces liver steatosis amelioration. Lysosomal acid
lipase (LAL) deficiency plays a role in fats accumulation in liver. To date, no studies have
assessed LAL activity in morbid obesity. The aim of our study is to evaluate VLCKD impact on
metabolic/vascular parameters and LAL activity in obese patients.
A VLCKD is administered for 25 days to 52 morbid obese patients (BMI 44.7±8.3 kg/m², age
49±12.5 years); at baseline and after diet we evaluated: BMI, glyco-lipidic pattern,
abdominal ultrasonography (liver steatosis and visceral fat area) and flow-mediated dilation
(FMD). In a subgroup of 20 patients we also tested lysosomal acid lipase (LAL)-activity. A
group of healthy normal weight subjects (age 43±13, BMI 22.8±2.6 kg/m²) was also included in
the study.
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