Clinical Trials Logo
  1. Home
  2. Keratoconus
  3. NCT04130334
  4. Details
NCT04130334 Clinical Trial

Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN

Keratoconus Clinical Trial

Official title:
Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN: a Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04130334
Other study ID # 10000
Secondary ID
Status Recruiting
Phase Phase 2/Phase 3
First received
Last updated
Start date June 1, 2018
Est. completion date March 1, 2020

Study information
Verified date May 2019
Source Shahid Beheshti University of Medical Sciences
Contact Sepehr Feizi, MD
Phone 009822591616
Email labbafi@hotmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Patients with KCN who undergo cornea transplantation divided to 2 groups:

Group1: After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea Group 2: After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea After suture removal, best corrected visual acuity, refractive error, corneal keratometry, irregularity of corneal surface and high order aberration of two groups will compare

Recruitment information / eligibility
Status Recruiting
Enrollment 52
Est. completion date March 1, 2020
Est. primary completion date June 1, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 15 Years and older
Eligibility Inclusion Criteria:

- Patients with KCN who undergo DALK surgery

Exclusion Criteria:

- Penetrating Keratoplasty surgery

- Other corneal diseases

- dystrophies

- Corneal graft rejection

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea
After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea
• : After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea
: After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea

Locations
Country Name City State
Iran, Islamic Republic of Ophthalmic Research Center Tehran

Sponsors (1)
Lead Sponsor Collaborator
Shahid Beheshti University of Medical Sciences

Country where clinical trial is conducted

Iran, Islamic Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary Best corrected visual acuity Snellen chart 14 months
Primary graft astigmatism Topography 14 months
See also
  Status Clinical Trial Phase
Recruiting NCT04570020 - Scleral Lens Fitting Using Wide-Field OCT
Recruiting NCT02921009 - McNeel Eye Center Corneal Crosslinking Study N/A
Completed NCT01691651 - Botulinum Toxin A for the Treatment of Keratoconus N/A
Terminated NCT02762253 - Study of the Safety and Effectiveness of Photochemically Induced Collagen Cross-Linking in Eyes With Keratoconus. Phase 2
Completed NCT01527708 - Accuracy of Curvature and Wavefront Aberrations of Posterior Corneal Surface, in Keratoconic and Post-CXL Corneas N/A
Completed NCT01527721 - Blurring Strength & Aberrometric Changes Following Corneal Cross-linking (CxL) and CxL Combined With Photorefractive Keratectomy (PRK) in Keratoconus N/A
Recruiting NCT00841386 - Treatment of Keratoconus Using Collagen Cross-Linking Phase 2/Phase 3
Completed NCT00347074 - A Clinical Study of Keratoconus in Asian Patients and Assessment of Different Topographic Patterns of Keratoconus in Asian Patients N/A
Completed NCT03187912 - Accelerated Corneal Cross-linking With Different Riboflavin Solutions Phase 3
Completed NCT00584285 - Corneal Topographer Fluorescein Patterns
Completed NCT03511495 - Reliability of Topography Measurements in Keratoconus
Not yet recruiting NCT05395650 - Cyanocobalamin as Photosensitizing Agent
Completed NCT04418999 - Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus Early Phase 1
Completed NCT05019768 - Topo-pachimetric Accelerated Epi-On Cross-linking Compared to Dresden Protocol Using Riboflavin With Vitamin E TPGS N/A
Completed NCT03235856 - Retrospective Digital Computer Analysis of Keratoconus Evolution - REDCAKE
Withdrawn NCT01789333 - Higher Irradiance in Keratoconus Ectasia N/A
Completed NCT05114928 - Correlation Between Q-value Changes and Progression of Pediatric Keratoconus.
Completed NCT03647046 - Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus N/A
Recruiting NCT04439552 - fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Recruiting NCT06100939 - Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus Phase 3