Astigmatism in Keratoconus Patients

Keratoconus Clinical Trial

Official title:

Comparison of Anterior and Posterior Corneal Astigmatism in Patients With Keratoconus and Controls

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03450213
• Other study ID #: Keratoconus
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 1, 2019
• Est. completion date: October 1, 2021

Study information

• Verified date: October 2018
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning, resulting in a cone-like bulge , which causing irregular astigmatism and vision impairment.

Description:

Keratoconus is the most common form of corneal ectasia, with an incidence of 50-230 per 100,000 persons.Pentacam used diagnose & detect the progression in patients with keratoconus and also provide a detailed information about corneal tomography and topography.

In the last few years, it has been shown that in healthy individuals the posterior corneal surface has not only a different amount of astigmatism but also a different alignment of the steep meridian.

The aim of this research is to compare the amount and axis alignment of anterior and posterior corneal astigmatism in keratoconus with a healthy controlled group .

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: October 1, 2021
• Est. primary completion date: October 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Patients diagnosed with keratoconus using the following criteria:

Specific diagnostic signs is asymmetric refractive errors with high progressive or irregular astigmatism, and elevated keratometry values, scissoring of the red reflex, Vogt striae, Fleischer rings, inferior or central steepening on topography with abnormal localized steepening .

Exclusion Criteria:

• Unwillingness to participate in the study .

• Corneal scarring.

• Any ectatic conditions that were not explicitly keratoconus such as keratoglobus and pellucid marginal degeneration .

• Previous ocular surgery.

Related Conditions & MeSH terms

• Astigmatism
• Keratoconus

Intervention

Device:
• Pentacam
Pentacam will be used to measure the magnitude and axis orientation of anterior and posterior corneal astigmatism.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (1)

Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998 Jan-Feb;42(4):297-319. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison between astigmatism in patients with keratoconus and normal people.	Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex	Two years