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Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes

Keratoconus Clinical Trial

Official title:
Protease and Cytokine Composition in Post Lens Tear Reservoir of Scleral Lenses for Keratoconic Eyes

Clinical Trial Summary

The purpose of this study is to investigate changes in the level of inflammatory mediators in the tear film of scleral contact lens wearers in a keratoconic population.

Clinical Trial Description

Scleral contact lenses are rigid gas permeable lenses designed to rest on the sclera while vaulting over the cornea with a fluid reservoir. The use of scleral contact lenses has become the current standard of practice as a nonsurgical management of corneal ectasia and ocular surface diseases. Cases have been recently presented of scleral lens wearers exhibiting adverse corneal findings and conjunctival injection from lens wear. These findings are likely associated with the mechanical and hypoxic effects due to poor fitting characteristics at the limbal area. Tear film analysis detecting changes in the levels of proteinases and cytokines have helped researchers gain a better understanding of the pathophysiology of complications in soft contact lenses wearers, dry eye, and keratoconus. Ultimately, this study will provide insights in relating scleral lens fitting characteristics and corneal and limbal physiological responses. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02806921
Study type Interventional
Source University of Waterloo
Contact
Status Completed
Phase N/A
Start date August 2016
Completion date February 15, 2018
View Details
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