Keratoconus Clinical Trial
Official title:
Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus
CACICOL20 is an ophthalmic solution based on the technology of RGTAs (ReGeneraTingAgents).
It consists of large biopolymers, imitating the structure of heparansulphate. The protecting
effect on different biological tissues and enhancement of wound healing has been described
in several studies.
Keratoconus is a relatively common disease, with incidences ranging from 1.3 to 25 per
100,000 per year across different populations. Corneal collagen cross-linking represents a
treatment option for these patients, aiming to prevent progression of the disease via
stabilization of corneal microstructure. Corneal epithelial removal prior to the ultraviolet
A/riboflavin cross-linking procedure significantly improves the outcome of the intervention,
due to ameliorated distribution of riboflavin.
The aim of the present study is to investigate the effect of CACICOL20 on corneal epithelial
wound closure after collagen cross-linking in patients with keratoconus. Results may lead to
an improved management and pain reduction of patients with corneal epithelial defects.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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