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Keratoconus clinical trials

View clinical trials related to Keratoconus.

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NCT ID: NCT04383301 Completed - Keratoconus Clinical Trials

Combined Corneal Wavefront-guided TPRK and ACXL Following ICRS Implantation in Management of Moderate Keratoconus

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Background: Keratoconus leads to gradual progressive loss of vision in young and adult patients. For visual rehabilitation and to hinder keratoconus progressionthe investigators designed this study to help the keratoconus patients to improve and stabilize their vision. Design: This is a prospective consecutive uncontrolled study. Patients and Methods: This study includes 36 eyes of 36 patients with moderate degree o keratoconus (KC) undergoing combined wave front guided transepithelial photorefractive keratectomy (TPRK) and accelerated corneal collagen crosslinking (ACXL) after intracorneal ring segment (ICRS) implantation. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent (MRSE), corneal indices based on Scheimpflug tomography, higher-order aberrations (HOAs) will be evaluated at baseline, after ICRS implantation, and at1, 3, 6, and 12 months after combined TPRK and CXL.

NCT ID: NCT04346992 Completed - Clinical trials for Keratoconus in Thyroid Gland Dysfunction

Prevalence Of Keratoconus Among Patients With Thyroid Gland Dysfunction

Start date: April 12, 2020
Phase:
Study type: Observational

Hormonal imbalances are likely to affect the corneal metabolism and may be also associated with Keratoconus. Among the various endocrinologic dysfunctions assumed so far, thyroid gland dysfunction (TGD) (hypo- or hyperthyroidism; comprised as TGD) is frequently associated with eye diseases such as Graves disease

NCT ID: NCT04313387 Completed - Clinical trials for Keratoconus, Artificial Intelligence, Support Vector Machine

Efficiency of an Algorithm Derived From Corneal Tomography Parameters to Distinguish Highly Susceptible Corneas to Ectasia From Healthy

Start date: January 1, 2012
Phase:
Study type: Observational

The objective of this study was to identify and build an algorithm through an imaging process using a support vector machine (SVM) with the tomography variables of cases with, KC, highly susceptible corneas to ectasia (HSCE), and healthy corneas and to compare this algorithm to BAD-D (Belin_Ambrosio Display) and PRFI (Pentacam Random Forest Index). The study included 148 eyes with KC, 351 with healthy corneas, and 88 eyes with HSCE.

NCT ID: NCT04177082 Completed - Keratoconus Clinical Trials

Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution

Start date: January 10, 2020
Phase: Phase 1
Study type: Interventional

Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions

NCT ID: NCT04174209 Completed - Keratoconus Clinical Trials

CHOICE OF SUBJECTIVE OCULAR REFRACTION TECHNIQUE AND CORNEAL TOPOGRAPHY OF KERATOCONUS

RE-CON
Start date: November 18, 2019
Phase: N/A
Study type: Interventional

Keratoconus is a rare evolving corneal ectasia that alters visual acuity. To improve spectacle-corrected visual acuity, various subjective refraction techniques can be used. The subjective refraction techniques of keratoconus-carrying patients have never been studied. The main hypothesis is that the most suitable subjective ocular refraction method varies with the corneal topography of the keratoconus. The main objective is to define the most appropriate refractive technique(s) based on corneal topographies in order to provide keratoconus-affected patients with the best spectacle-corrected visual acuity.

NCT ID: NCT04168112 Completed - Postoperative Pain Clinical Trials

Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Start date: February 12, 2020
Phase: Phase 4
Study type: Interventional

There is no standard of care medication regimen for the management of pain and inflammation post-corneal crosslinking (CXL), although most cornea specialists agree on use of an antibiotic and steroid eye drop in the immediate postoperative period. However, steroid tapering schedule and use of additional topical non-steroidal anti-inflammatory (NSAID) eyedrops vary amongst practitioners. The goal of this study is to compare postoperative pain scores between patients receiving a tapering dose of topical steroids over 1-month post-CXL, versus those receiving an intracanalicular dexamethasone insert.

NCT ID: NCT04062435 Completed - Keratoconus Clinical Trials

Corneal Uptake of Riboflavin Eye Drops

Start date: December 1, 2019
Phase: N/A
Study type: Interventional

The overall objective of this study is to optimise the corneal cross-linking standard protocol in terms of a more economical use of the resource "medical personnel" and in terms of increased patient participation. If it can be shown that the riboflavin necessary for corneal cross-linking does not necessarily have to be applied directly on the cornea (as currently performed by the nurses), but can also be applied in the inferior fornix (as it would be performed by patients in the context of self-application), then it would be conceivable to transfer this task from medical staff to the patients.

NCT ID: NCT03990506 Completed - Keratoconus Clinical Trials

Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus

Start date: April 2, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the efficacy, safety and postoperative ocular discomfort by comparing individually customized Photorefractive intrastromal crosslinking (PiXL) for progressive Keratoconus. The study compares two different protocols, PiXL with corneal epithelium debridement (Epi-off) and PiXL without epithelium debridement in high oxygen environment (Epi-on), with the hypothesis that Epi-on gives less postoperative ocular discomfort.

NCT ID: NCT03753009 Completed - Keratoconus Clinical Trials

Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric Patients. Three Year Follow up.

Start date: January 1, 2013
Phase:
Study type: Observational

To compare 3 year iontophoretic transepithelial corneal cross-linking (I-ON CXL) outcomes with epithelium-off collagen cross-linking (epi-off CXL)in pediatric patients.

NCT ID: NCT03661164 Completed - Keratoconus Clinical Trials

Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients

Start date: May 1, 2013
Phase:
Study type: Observational

To report three year follow up in pediatric patients with keratoconus after iontophoretic transepithelial corneal cross-linking (CXL) to assess preoperative factors that may influence ectasia progression