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ITCH clinical trials

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NCT ID: NCT06245564 Not yet recruiting - Itch Clinical Trials

Effect of Ketamine, Amitriptyline and Their Combination on Histaminergic and Non-histaminergic Itch

Start date: June 17, 2024
Phase: N/A
Study type: Interventional

Chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals. Furthermore, there is a lack of efficient treat-ment options for chronic itch. Topical ketamine cream has been used successfully to relieve various forms of pain, and we hypothesize that topical ketamine relieves itch through a mechanism of action comparable to that in pain relief. The aim of this project is to evaluate the effects of ketamine both alone and in combination with amitriptyline on histaminergic and non-histaminergic itch induced by histamine and cowhage, respectively.

NCT ID: NCT06201715 Not yet recruiting - Prurigo Nodularis Clinical Trials

Efficacy and Safety of Tofacitinib in Patients With Prurigo Nodularis

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

The goal is to evaluate the efficacy and safety of tofacitinib in treating refractory prurigo nodularis.The main questions it aims to answer are 1. whether tofacitinib is effective in treating prurigo nodularis in the longpterm. 2. whether tofacitinib is safe in prurigo nodularis patients in the longpterm.

NCT ID: NCT06036589 Completed - Itch Clinical Trials

Characterization of Bovine Adrenal Medulla as a Model of Non-histaminergic Itch

Start date: March 10, 2022
Phase: N/A
Study type: Interventional

With this experiment, the experimenter wish evaluate the role of TRPA1 on non-histaminergic itch induced by BAM8-22

NCT ID: NCT05678309 Not yet recruiting - Pruritus Clinical Trials

Establishment of a Patient Library in Patients With Pruritus Sine Materia

PRURITHEQUE
Start date: April 1, 2023
Phase:
Study type: Observational [Patient Registry]

Very little is currently known about the pathophysiology of pruritus sine materia according to the etiology. The creation of this cohort should make it possible to improve our clinical and biological knowledge according to the etiology, by collecting blood, skin, feces, and clinical data.

NCT ID: NCT05460598 Active, not recruiting - Itch Clinical Trials

The Effect of Cooling With a Bed Topper and Linen on Itch in Clinical Routine

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

This single-blinded (only patients blinded) study is to assess the effect of cooling beddings on itch. The primary objective is to test whether or not the use of the cooling beddings during 3 days can add at least 20% improvement in (nocturnal) itch as measured by the 0-10 NRS in comparison to a control group that does not use the cooling beddings.

NCT ID: NCT05249387 Completed - Itch Clinical Trials

Characterization of Bovine Adrenal Medulla as a New Surrogate Model of Non-histaminergic Itch

Start date: February 11, 2022
Phase: N/A
Study type: Interventional

With this experiment, the experimenter wish evaluate the role of TRPA1 on non-histaminergic itch induced by BAM8-22

NCT ID: NCT05195177 Enrolling by invitation - Itch Clinical Trials

Testing Protocol to Efficiently Induce Itch

ELIT
Start date: November 25, 2021
Phase: N/A
Study type: Interventional

This subproject aims to evaluate a new nerve excitability protocol to induce itch in healthy controls by electrical stimulation. Itch has many similarities with pain, and the nerve fibers that mediate the two sensations probably have the same morphological and excitability properties. The method used in this project will be the same as our research group uses for studying nociceptor fibers (PTT technique), but the focus is on the itch sensation. Since the itch fibers also terminate in the epidermis, our PTT technique should also be able to activate itch fibers, similar to pain fibers. If itch could be effectively induced by electrical stimulation, this would generate a valuable tool for studying itch in healthy controls. The sub-project takes place in 2 sessions (2 hours each).

NCT ID: NCT05024851 Terminated - Neuropathic Pain Clinical Trials

Psychogenic and Neurogenic Components in Patients With Psychogenic or Neuropathic Pruritus

PRURINEURO
Start date: August 25, 2021
Phase:
Study type: Observational

Scientific research on pruritus is in intensive development, with significant advances in understanding its pathophysiology. The causes of pruritus are very huge; they can be classified into different categories; we can find dermatological causes, systemic causes, neuropathic or neurological causes, psychogenic or even idiopathic causes. The diagnosis of psychogenic pruritus is often over stated, when no cause is found; therefore, it is important to see what is really relieving from psychic so as not to over-diagnose and adopt a therapy more in line with the real problem of the patient. In daily practice, it seems to have a tendency to separate psychogenic and neurogenic etiologies in the diagnosis of neuropathic or psychogenic pruritus. In the case of patients with psychogenic pruritus and neuropathic pruritus, no study has attempted to study the respective part of psychogenic and neurogenic components. Consequently, it would therefore be interesting to assess the areas of superposition and distinction of neuropathic and psychogenic pruritus. The aim of this pilot study is to assess the psychogenic and neurogenic components of psychogenic pruritus and neuropathic pruritus in order to improve understanding of the mechanism and therefore their management. The main objective of this study is to highlight the differences and the potential common characteristics between psychogenic and neuropathic pruritus in order to improve the differential diagnosis between these two pathologies. The secondary objective of this study is to describe the psychogenic and neurogenic characteristics of psychogenic and neuropathic pruritus.

NCT ID: NCT04858360 Completed - Itch Clinical Trials

Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens

Start date: November 15, 2021
Phase: N/A
Study type: Interventional

With this experiment, we want to use to investigate whether repeated application of EMLA cream as a tool to modulate non-histaminergic itching, which is produced using small needles from the plant mucuna pruriens (it is known that antihistamine does not attenuate this form of itch) and we want to compare the effect of short (1 hour) and prolonged (3 hours) application of EMLA. The sub-project takes place in 3 sessions over a period of 3 consecutive days (24 hours apart). All sessions will be identical.

NCT ID: NCT04711044 Completed - Itch Clinical Trials

Investigation of a New Human Model for Itch

Start date: February 1, 2021
Phase: N/A
Study type: Interventional

This third sub-project aims to evaluate the interaction between the TRPM8 receptor and pruritus by studying the anti-pruritic effect of TPRM8-agonist L-menthol on histaminergic and non-histaminergic itch induced using three different pruritogens: histamine, cowhage and papain.