Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease

Ischemic Stroke Clinical Trial

Official title:

Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease: A Cross-sectional Study in Thai Patients

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02720861
• Other study ID #: COA No.282/2015
• Status: Recruiting
• Phase: N/A
• First received: March 15, 2016
• Last updated: March 25, 2016
• Start date: March 2015
• Est. completion date: June 2016

Study information

• Verified date: March 2016
• Source: Chulalongkorn University
• Contact: Suporn Travanichakul, MD
• Phone: 0858054513
• Email: stravanichakul[@]yahoo.com
• Is FDA regulated: No
• Health authority: Thailand: Institutional Review Board
• Study type: Observational [Patient Registry]

Clinical Trial Summary

To explore the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease in Thai patients.

Description:

This is an cross-sectional observational study in Chulalongkorn hospital, to determine the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were admitted in Chulalongkorn Hospital for acute ischemic stroke treatment.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: June 2016
• Est. primary completion date: March 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Nationality in Thailand

• Age equal or more than 18 years

• Clinical and imaging diagnosis of acute ischemic stroke

• Patient consent to participate in the research

Exclusion Criteria:

• High risk for cardioembolic stroke by TOAST classification

• Contraindication for venipuncture

• Pregnancy or breast feeding patient

• History of head and neck radiation

• Down's syndrome

• Marfan syndrome

• Autoimmune disease such as SLE

• Ongoing malignancy or remission of malignancy less than 1year

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Cerebrovascular Disorders
• Ischemia
• Ischemic Stroke

Intervention

Genetic:
• DNA sequencing
withdraw 3m blood from vein only once during the whole design to analyse on DNA sequencing on RNF213 rs112735431 Gene

Locations

Country	Name	City	State
Thailand	Suporn Travanichakul	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Chulalongkorn University

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of Participants With RNF213 rs112735431 Gene polymorphism		1 year	No