Ischemic Heart Disease Clinical Trial
Official title:
Cerebral Oxidative and Inflammatory Stress and Cerebral Hemodynamics During and After Coronary Artery Bypass Grafting With Use of Cardiopulmonary Bypass
Purpose:
The purpose of this study is to examine cerebral oxidative and inflammatory stress and
cerebral hemodynamics during and after coronary artery bypass grafting and correlate with
postoperative cognitive function.
Postoperative cognitive decline is a well-known and well-described complication following
coronary artery bypass grafting. Severity ranges from postoperative delirium to stroke, but
the majority of patients with postoperative cognitive decline following coronary artery
bypass grafting have decline in recent and remote memory in particular.
The reason for the cognitive decline is still not fully understood though many reasons have
been proposed.
Inflammation and oxidative stress may contribute to the postoperative cognitive dysfunction
which may also be in combination with a reduced cerebral autoregulation.
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