Ischemic Heart Disease Clinical Trial
Official title:
Comparisons of Myocardial Injury After Using Different Anesthetics Regimens for Off-pump Coronary Artery Bypass Surgery: Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimen
In patients undergoing off-pump coronary artery bypass (OPCAB) surgery with different anesthesia regimens: remifentanil (0.75 mcg/kg/min) and propofol (TCI effect-site concentration 0.8-1.5 mcg/ml) (Group -RP); remifentanil (0.75 mcg/kg/min) and sevoflurane (end-tidal 0.8 vol%) (Group-RS), or sevoflurane (end-tidal 1.2-2.8 vol%)-sufentanil (TCI effect site concentration 0.35-0.75 ng/ml) (Group-SS), intergroup difference in the level of Troponin I (c-TnI) and creatinine kinase subtype-MB is determined before surgery (control), during vascular graft harvesting (harvesting), after completing graft construction (postgrafting), and one day after surgery (postoperative).
To determine the difference of myocardial injury upon using different anesthesia regimens:
remifentanil-based regimen versus sevoflurane-sufentanil balanced regimen.
Patients undergoing off-pump coronary artery bypass (OPCAB) surgery are randomly allocated
to get remifentanil (0.75 mcg/kg/min) and propofol (TCI effect-site concentration 0.8-1.5
mcg/ml) (Group -RP), remifentanil (0.75 mcg/kg/min) and sevoflurane (end-tidal 0.8 vol%)
(Group-RS), or sevoflurane (end-tidal 1.2-2.8 vol%)-sufentanil (TCI effect site
concentration0.35-0.75 ng/ml) (Group-SS).
Intergroup difference in the level of Troponin I (c-TnI) and creatine kinase-MB is
determined before surgery (control), during vascular graft harvesting (harvesting), after
completing graft construction (postgrafting), 1 day after surgery (postoperative).
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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