Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)

Ischemic Heart Disease Clinical Trial

Official title:

Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01699802
• Other study ID #: 2012/148
• Status: Completed
• Phase: N/A
• First received: September 25, 2012
• Last updated: May 13, 2015
• Start date: September 2012
• Est. completion date: December 2014

Study information

• Verified date: May 2015
• Source: Region Skane
• Contact: n/a
• Is FDA regulated: No
• Health authority: Sweden: Medical Products Agency
• Study type: Interventional

Clinical Trial Summary

The purpose is to investigate how the adsorptive capacity of the active carbon filter to carbon dioxide in an anaesthetic gas reflector (AnaConDa) is affected by adding inhaled anaesthetic agent.

The hypothesis is that addition of inhaled anaesthetic agent will affect the amount of adsorption of carbon dioxide to the active carbon and thereby affect rebreathing of carbon dioxide.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: December 2014
• Est. primary completion date: December 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• elective coronary artery by-pass graft surgery

• elective valve replacement surgery

• normal left ventricular ejection fraction on preoperative echocardiography

Exclusion Criteria:

• obstructive lung disease

• restrictive lung disease

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Coronary Artery Disease
• Ischemic Heart Disease
• Myocardial Ischemia

Intervention

Other:
• Inhaled anaesthetic agent

Locations

Country	Name	City	State
Sweden	Skane University Hospital Lund, Cardiothoracic Intensive Care	Lund

Sponsors (1)

Lead Sponsor	Collaborator
Region Skane

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Volume of carbon dioxide rebreathing from an anesthetic gas reflector	Tidal carbon dioxide volume rebreathed from an anesthetic gas reflector correlated to concentration of delivered anesthetic gas.	2 hours	No
Secondary	Quantification of ventilatory requirements to maintain isocapnia with the use of an anesthetic gas reflector.	Changes of tidal volume required to maintain constant alveolar ventilation will be assessed by continuous measurement of exhaled tidal carbon dioxide volume, the latter to be maintained at a constant value.	2 hours	No