Ischemic Heart Disease Clinical Trial
Official title:
Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass
The purpose of this study was to see if the heart-lung machine involved in cardiac surgery increases the movement of activated white blood cells from the bloodstream into the patient's tissues and also to see if aprotinin usage during surgery reduces this effect.
It has long been known that exposure of blood to the heart-lung bypass machine can trigger a
whole-body inflammatory response in cardiac surgery patients that is linked to activation of
circulating white blood cells. The investigators propose to use a technique to track the
movement of white blood cells into the skin of patients during bypass surgery. The skin
blisters will be elicited by application of the blistering agent cantharidin to the forearm
of volunteer patients. This will allow the investigators to study the activation state of
white blood cells that enter tissues during bypass surgery and to determine whether
aprotinin has any beneficial effect with regards to inflammatory status of these cells.
The investigators propose that white blood cell trafficking into the blisters will increase
following the use of the heart-lung machine and that the effect of aprotinin will be to
ablate this.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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