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Ischemic Cardiomyopathy clinical trials

View clinical trials related to Ischemic Cardiomyopathy.

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NCT ID: NCT05745571 Active, not recruiting - Heart Failure Clinical Trials

Molecular Pathways of Cardiac Remodellation in Patients With Acute and Chronic Left Ventricular Disfunction

HFrEF
Start date: January 7, 2019
Phase: N/A
Study type: Interventional

Chronic heart failure represents an extremely complex clinical syndrome, defined as the inability of the heart muscle to generate a volume adequate to the metabolic needs of peripheral tissues, or to do so only in the face of high filling pressures intracavity. Heart failure is one of the leading causes of mortality and morbidity in Western countries. Despite advances in the therapeutic field, the prognosis of patients with heart failure of ischemic and non-ischaemic aetiology still remains unfavorable, with a mortality rate of 50% 5 years after the first hospitalization.Therefore, a deeper understanding of the pathophysiological mechanisms involved in heart failure and adverse ventricular remodeling is essential.

NCT ID: NCT04489355 Active, not recruiting - Clinical trials for Cardiovascular Diseases

The Effectiveness of Surgical Treatment of Patients With Ischemic Cardiomyopathy

Start date: January 28, 2013
Phase:
Study type: Observational

The study focuses on the development of a new personalized approach to diagnostics and surgical treatment of patients with ischemic cardiomyopathy. The algorithm for selection of patients for certain type of cardiac surgery will be developed. The models for prediction of the risks and outcomes of cardiac surgery will be elaborated to reduce the rate of complications in the early and long-term postoperative period in patients with ischemic cardiomyopathy. Imaging modalities, methods for assessement of structural and functional state of the myocardium, biochemistry testing, immunohistochemical examination, and myocardial biopsy studies will be used to achieve these goals.

NCT ID: NCT03845127 Active, not recruiting - Heart Failure Clinical Trials

Randomized Evaluation and Verification of Ventricular Enhancement

REVIVE-HF
Start date: January 1, 2020
Phase: N/A
Study type: Interventional

A prospective, multi-center, dual-arm randomized controlled study comparing treatment of ischemic cardiomyopathy induced heart failure with the Revivent TC System plus Guideline Directed Medical Therapy (GDMT) compared to GDMT alone.

NCT ID: NCT03493516 Active, not recruiting - Clinical trials for Congestive Heart Failure

Prediction of ARrhythmic Events With Positron Emission Tomography II

PAREPET II
Start date: April 8, 2018
Phase:
Study type: Observational

Sudden cardiac death continues to be a major contributor to mortality in patients with ischemic cardiomyopathy. While implantable defibrillators can prevent death from ventricular arrhythmias, our current approach to identify patients at highest risk primarily rests on demonstrating a reduction in left ventricular ejection fraction less than 35%. The purpose of this observational cohort study is to prospectively test whether this can be enhanced by quantifying the amount of sympathetic denervation, left ventricular end-diastolic volume or brain natriuretic peptide levels.

NCT ID: NCT03231189 Active, not recruiting - Clinical trials for Ischemic Cardiomyopathy

Cardiac MRI in Front Line for the Diagnosis of Coronary Artery Disease as the Etiology of Left Ventricular Dysfunction

CAMAREC
Start date: May 15, 2018
Phase:
Study type: Observational

When a patient is newly diagnosed of systolic dysfunction without obvious etiology (such as rhythmic, ischemic, or valvular disease), most of the time a coronary angiography is performed. In this situation, the investigators aim to evaluate a strategy with CMR as the front line exam, and invasive coronary angiography performed only in case of ischemic scar on CMR

NCT ID: NCT02293603 Active, not recruiting - Heart Failure Clinical Trials

Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC)

DYNAMIC
Start date: November 2014
Phase: Phase 1
Study type: Interventional

To determine the safety profile of CAP-1002 administered by multi-vessel intracoronary infusion in subjects with DCM. The study will further explore safety and exploratory efficacy endpoints of CAP-1002.

NCT ID: NCT01643330 Active, not recruiting - Heart Failure Clinical Trials

A Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure

CUPID-2b
Start date: July 2012
Phase: Phase 2
Study type: Interventional

The purpose of this trial is to assess whether MYDICAR can reduce the frequency and/or delay heart failure related hospitalizations in persons with advanced heart failure when added to their maximal and optimized therapy.

NCT ID: NCT00962364 Active, not recruiting - Heart Failure Clinical Trials

Long-term Evaluation of Patients Receiving Bone Marrow-derived Cell Administration for Heart Disease

BMC registry
Start date: October 2001
Phase:
Study type: Observational

This study will provide follow-up information and care of patients who have undergone autologous intracoronary bone marrow cell administration at our institution. Patients are monitored for their response to treatment, progression of heart failure and coronary artery disease, and potential later occurring effects of the administered bone marrow cells. Patients are eligible for this follow-up study if they have received their first intracoronary bone marrow cell administration for the treatment of cardiac disease at our institution from 2001 ongoing. Participants are generally seen in the clinic at 12 months and 5 years after cell administration, in the meantime regular yearly telephone contacts are performed until 10 years after cell transplantation. The detailed description contains the planned procedures that are performed during the clinical visits and, if necessary, at additional contacts.