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Ischemic Cardiomyopathy clinical trials

View clinical trials related to Ischemic Cardiomyopathy.

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NCT ID: NCT01603706 Completed - Clinical trials for Ischemic Cardiomyopathy

Radial Strain ECHO-Guided Implantation of Cardiac Resynchronization Therapy

RAISE-CRT
Start date: May 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the use of radial strain imaging using speckle tracking analysis to predict the response to CRT in patients with ischemic cardiomyopathy (ICMP) with NYHA functional class 2-4 heart failure and a standard guideline-based CRT indication. Thus assessing the value of lead localization determined by radial strain imaging in a prospective, randomized manner.

NCT ID: NCT01557465 Completed - Heart Failure Clinical Trials

Mechanical Alternans Study

MAS
Start date: November 2009
Phase: N/A
Study type: Observational

The purpose of this study is to determine whether mechanical alternans (alternating strong and weak heart beats with a constant beat-to-beat interval), can be used to predict malignant ventricular arrhythmias, requiring defibrillation or appropriate ICD therapies, and to predict progression of heart failure and death.

NCT ID: NCT01474486 Completed - Clinical trials for Congestive Heart Failure

Feasibility and Effectiveness of Micronutrients as Palliative Care Therapy in Patients With Congestive Heart Failure

Start date: April 2010
Phase: N/A
Study type: Interventional

The purpose of this project is to conduct a preliminary test of the feasibility of a multi-micronutrient intervention to improve micronutrient status, cardiac function and quality of life in Veterans with Congestive Heart Failure (CHF).

NCT ID: NCT01400334 Completed - Clinical trials for Ischemic Cardiomyopathy

Prediction of ARrhythmic Events With Positron Emission Tomography

PAREPET
Start date: July 2004
Phase:
Study type: Observational

The hypothesis of PAREPET is that hibernating myocardium (viable myocardium with reduced resting flow) and/or viable but denervated myocardium can predict the risk of sudden death in subjects with ischemic cardiomyopathy.

NCT ID: NCT01288560 Completed - Clinical trials for Coronary Artery Disease

IMAGE-HF Project I-A: Cardiac Imaging in Ischemic Heart Failure (AIMI-HF)

AIMI-HF
Start date: January 2011
Phase: N/A
Study type: Interventional

Medical imaging is one of the fastest growing sectors in health care and increases in utilization underscore the need to ensure imaging technology is developed and used effectively. Evaluation of the clinical and economic impact of such imaging lags behind the technology development. Heart failure (HF) represents the final common pathway for most forms of heart disease and morbidity and mortality remain high. There is a need to identify imaging approaches that have a positive impact on therapy decisions, patient outcomes and costs. As well as standard methods to evaluate new and emerging techniques to better test their potential in a clinical management setting. PRIMARY OBJECTIVES: to compare the effect of HF imaging strategies on the composite clinical endpoint of cardiac death, MI, resuscitated cardiac arrest and cardiac re-hospitalization (WHF, ACS, arrhythmia). Patients with an ischemic heart disease (IHD) etiology will follow HF imaging strategy algorithms according to the question(s) asked by the physicians (is there ischemia and/or viability), in agreement with their local practices for standard and alternative imaging. SECONDARY OBJECTIVES: 1. To evaluate the effect of imaging modalities within and between the imaging subgroups (advanced (CMR and PET), PET, MRI and standard (SPECT)) on the primary and secondary outcomes in patients being evaluated either for viability and/or ischemia. 2. To evaluate the impact of adherence to recommendations between modalities on outcomes in patients being evaluated for either viability or ischemia. 3. To compare the effect of HF imaging strategies on: 1. The incidence of revascularization procedures (PCI, CABG, none) and the interaction of the imaging strategy and types of revascularization on outcomes 2. LV remodeling: LV volumes, LVEF, 3. HF symptoms, NYHA class 4. QOL (MLHFQ, the EQ5D) 5. The evolution of serum prognostic markers in HF (e.g. BNP, RDW, hs-cTnT, hs-CRP, ST2) 6. Health economics: Costs estimated through regression analysis and cost effectiveness assessed through decision modeling. 7. The safety of imaging tests measured by cumulative radiation, adverse reactions to imaging contrast agents and stress testing agents will also be determined. 8. The evolution of renal function (eGFR) and LV remodeling-associated biomarkers (e.g. PIIINP, OPN). 9. Event rates of each component of the composite endpoint as well as the combined endpoint of CV death and HF hospitalization 10. All-cause mortality

NCT ID: NCT01215253 Completed - Heart Failure Clinical Trials

Ranolazine Implantable Cardioverter-Defibrillator Trial

RAID
Start date: September 2011
Phase: Phase 3
Study type: Interventional

The purpose of the study is to see how effective a drug called ranolazine is in reducing the risk of ventricular arrhythmia and death in people with implantable cardioverter-defibrillators (ICDs). This drug will be used with standard medications that is routinely prescribed in enrolled patients.

NCT ID: NCT00981006 Completed - Clinical trials for Congestive Heart Failure

AutoLogous Human CArdiac-Derived Stem Cell to Treat Ischemic cArdiomyopathy (ALCADIA)

ALCADIA
Start date: April 2010
Phase: Phase 1
Study type: Interventional

The aim of this study is to evaluate the safety and efficacy on the transplantation of autologous human cardiac-derived stem cells (hCSCs) with the controlled release of basic fibroblast growth factor (bFGF) to severe refractory heart failure patients with chronic ischemic cardiomyopathy concordance with reduced left ventricular dysfunction (15%≦LVEF≦35%).

NCT ID: NCT00896142 Completed - Heart Failure Clinical Trials

Optima Coronary Artery Disease (CAD) (Optimal Mechanical Evaluation)

Start date: October 2006
Phase: N/A
Study type: Observational

To evaluate the impact of left ventricular (LV) lead location on LV mechanical function.

NCT ID: NCT00824005 Completed - Clinical trials for Ischemic Cardiomyopathy

Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)

Start date: March 2009
Phase: Phase 2
Study type: Interventional

Coronary artery disease (CAD) is a common disorder that can lead to heart failure. Not all people with CAD are eligible for today's standard treatments. One new treatment approach uses stem cells—specialized cells capable of developing into other types of cells—to stimulate growth of new blood vessels for the heart. This study will determine the safety and effectiveness of withdrawing stem cells from someone's bone marrow and injecting those cells into the person's heart as a way of treating people with CAD and heart failure.

NCT ID: NCT00665301 Completed - Clinical trials for Congestive Heart Failure

Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000

Start date: March 2008
Phase: N/A
Study type: Observational

The purpose of this study is to compare cardiac output results obtained using the thermodilution push technique with the Pulmonary Arterial Catheter (PAC) to the predicted cardiac output results obtained from the non-invasive FloWave™ 1000 device.