Cardiovascular Disease Clinical Trial
Official title:
Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
To adjust our forearm model for ischemia reperfusion injury, in order to used it for
assessment of ischemia reperfusion damage in elderly and patients.
To test the effect of ischemic postconditioning on ischemia reperfusion injury in healthy
volunteers, using Annexin binding after repetitive handgripping.
Recently, ischemic postconditioning has been identified as a protective intervention against ischemia-reperfusion injury. In animal studies, the signalling pathway of this (impressive) protective phenomenon is very similar to ischemic preconditioning. It opens a new avenue of post-reperfusion interventions with drugs that have been shown to mimic ischemic preconditioning. Before we can study this phenomenon in our forearm ischemia-reperfusion model, we need additional validating experiments. The purpose of this study proposal is to provide these data. ;
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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