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Intraoperative Complications clinical trials

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NCT ID: NCT04256928 Not yet recruiting - Clinical trials for Intraoperative Complications

The Effect of Hair Removal on Intraoperative Contamination

Start date: February 15, 2020
Phase: N/A
Study type: Interventional

A prospective, non-blinded, randomized controlled trial with the purpose of investigating, whether preoperative electrical clipping of body hair affects the risk of intraoperative contamination. The primary investigators hypothesis is this: Preoperative electrical clipping of body hair in the operative field lowers the risk of intraoperative contamination. 200 male participants, 18 years or older, with a planned primary knee replacement surgery, will be enrolled. During surgery, four microbiological samples will be taken from each participant. The primary outcome is whether there is intraoperative contamination of the surgical site or not, determined by identification of any grown bacteria from the samples. If this study finds, that the contamination rate is lowered by preoperative electrical clipping of body hair, it will provide a cost-effective method of reducing the risk of intraoperative contamination and consequent postoperative infection, a solid argument for a change of current guidelines for preoperative hair removal, and provide additional information pointing towards body hair as a possible explanation for the increased infection rate in men.

NCT ID: NCT04182256 Completed - Clinical trials for Liver Transplant; Complications

Magnetic Spiderman for Preparation of Liver Donation

MSPLD
Start date: October 1, 2020
Phase: N/A
Study type: Interventional

Due to many vascular branches on the supra-hepatic vena cava (SHVC) and infra-hepatic vena cava (IHVC), in the whole procedures of preparation of liver donation, preparation of hepatic vena cava (HVC) is the most key and troublesome step. Magnetic Spiderman (MS) is a novel surgical instrument, designed and created to solve the vital problems of preparation of liver donation's HVC. Therefore, the aim of this study is to evaluate the feasibility and security of MS when using it prepare the liver donation's HVC.

NCT ID: NCT04086199 Recruiting - Clinical trials for Back Pain Lower Back Chronic

Spinal Approach for Lumbar Active Discopathy

Start date: January 1, 2020
Phase:
Study type: Observational

The study aims to study the impact on different surgical approaches for lumbar active discopathy. This inflammatory disease of the disc and adjacent vertebral endplates can induce low back pain with inflammatory-like features. Lumbar fusion is proposed to the patient when conservative management is not enough. This fusion can be obtained by an anterior muscle sparring approach or by a posterior muscle decaying approach. The goal with this single center retrospective study is to identify the surgical approach that offers to the patient the better long term functional outcome. A phone call would allow us to ask patients a few questions: - Mcnab's criteria - Roland Morris Disability Questionnaire The patients medical file review would also allow us to identify: - the length of hospital stay for the discectomy (in days) - incidence of Failed Back Surgery Syndrome - incidence of redo surgeries - incidence of adjacent level diseases - incidence of dural tears and eventual complications (meningitis, orthostatic headaches,...) - incidence of iliac vessels injuries and eventual complications (thrombosis, need for revascularisation,...)

NCT ID: NCT04020900 Completed - Anesthesia Clinical Trials

Respiratory Management of Children Under Anaesthesia

PEDIAVENT
Start date: June 21, 2017
Phase:
Study type: Observational

Ventilation management in paediatric anaesthesia remains difficult because of the wide range of age and weight, and therefore practices are heterogeneous. In adults, protective ventilation during anesthesia is now a standard of care but in children there is no level of evidence to recommend it. The aim of the study was to describe current practice and the factors associated with the use of high tidal volume during anaesthesia in children in France.

NCT ID: NCT03974321 Completed - Myocardial Injury Clinical Trials

Intraoperative Hypotension and Perioperative Myocardial Injury

Start date: May 1, 2019
Phase:
Study type: Observational [Patient Registry]

Acute myocardial infarction (MI) is a significant complication following non-cardiac surgery. We sought to evaluate incidence of perioperative MI, its preoperative - and intraoperative - risk factors and outcomes after this complication.

NCT ID: NCT03913650 Completed - Pain, Postoperative Clinical Trials

The Influence of Peripheral Nerve Blocks in Patients Undergoing Limb Orthopedic Surgery

Start date: May 15, 2017
Phase: N/A
Study type: Interventional

To investigate pre-op peripheral nerve block in reducing peri-op IL-6 level and post-op pain

NCT ID: NCT03901599 Completed - Anesthesia Clinical Trials

Protective Ventilation Based on Alveolar Ventilation in Children

PROVENTIPED
Start date: May 16, 2019
Phase:
Study type: Observational

Protective ventilation decreased morbidity and mortality in adults' patients and is now a standard of care in intensive care unit and in anesthesiology. In children, there is no evidence in the literature to recommend protective ventilation during anaesthesia. Moreover the ratio of instrumental dead space to tidal volume is higher in children than in adults. Therefore, it is difficult to propose an "optimal" tidal volume for all children. The objective of this study is to evaluate the use of alveolar ventilation (estimated by the volumetric capnography) in children under anesthesia. The hypothesis is that in children, alveolar ventilation reported to ideal body weight is a constant to maintain normocarbia, unlike the tidal volume.

NCT ID: NCT03869775 Recruiting - Clinical trials for Anesthesia; Adverse Effect

Perfusion Index Changes in Cardiovascular Autonom Neuropathia Type-2 Dm Whit Spinal Anesthesia

PI
Start date: December 1, 2017
Phase:
Study type: Observational

Cardiovascular autonomic neuropathy in diabetic patients, hypertension, sympathovagal imbalance, orthostatic hypotension, painless myocardial infarction, ischemia, left ventricular dysfunction, cardiac sympathetic and parasympathetic innervation disturbances, qt interval prolongation and sudden deaths observed. The purpose of this study is to evaluate the relationship between cardiovascular autonomic neuropathy and perfusion index in spinal anesthesia

NCT ID: NCT03837535 Completed - Myocardial Injury Clinical Trials

Myocardial Infarction in the Perioperative Setting

MIPS
Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

Acute myocardial infarction (AMI) is a significant complication following non-cardiac surgery. The investigators sought to evaluate incidence of perioperative AMI, its preoperative and intraoperative risk factors and the outcomes after this complication.

NCT ID: NCT03697330 Completed - Clinical trials for Intraoperative Complications

Liberal Versus Restrictive Fluid Protocols in Adults

Start date: January 28, 2018
Phase: Phase 2
Study type: Interventional

The term acute kidney injury (AKI) is used to describe a rapid deterioration (hours to days) of renal function. This rapid deterioration leads to accumulation of plasma waste products, such as urea and creatinine. Accumulation of urea and other nitrogen-containing substances in the blood stream lead to a number of symptoms, such as fatigue, loss of appetite, headache, nausea and vomiting. Marked increases in the potassium level can lead to irregularities in the heartbeat, which can be severe and life-threatening. Fluid balance is frequently affected, though blood pressure can be high, low or normal. Pain in the flanks may be encountered in some conditions (such as thrombosis of the renal blood vessels or inflammation of the kidney); this is the result of stretching of the fibrous tissue capsule surrounding the kidney. Perioperative AKI is a leading cause of morbidity and mortality; It is associated with increased risk of sepsis, anemia, coagulopathy, and mechanical ventilation. The first publication of consensus criteria for AKI was published in 2004. The system was named RIFLE (risk, injury, failure, loss of kidney function and end-stage renal failure) and used sCr or urine output to define AKI. Later, in 2007, a modified definition of the RIFLE criteria was published by the Acute Kidney Injury Network (AKIN) .Although the AKIN criteria evolved from the RIFLE criteria, a major advance was the understanding that even small changes in sCr concentrations are associated with increased morbidity and mortality. The AKIN criteria allowed definition of AKI even without knowledge of baseline sCr. In 2012, a clinical practice guideline of AKI was proposed by the Kidney Disease Improving Global Outcomes (KDIGO) Foundation. The guideline included a comprehensive review of AKI definition, risk assessment, diagnosis, prevention, treatment and renal replacement therapy. A common practice to maintain effective blood volume and thus kidney perfusion is intravenous (I.V.) hydration. Correcting hypovolemia is an essential perioperative hemodynamic goal and appropriate hydration is considered important for the avoidance of AKI. Perioperative fluid therapy has been studied extensively, but the optimal strategy remains controversial and uncertain. Much of the current debate surrounds the type of fluids administered (colloid versus crystalloid), the total volume administered (restrictive versus liberal), and whether the administration of fluids should be guided by hemodynamic goals (goal directed [GD] versus not goal directed). Administering a large amount of I.V. fluid in the perioperative period is a common clinical practice. Although fluid loading may expand intravascular space, improve organ perfusion or tissue oxygenation and reduce minor postoperative complications in laparoscopic surgery, excessive fluid may also increase some perioperative complications. Intraoperative urine output is often monitored but rarely responds to fluid administration. Clearance of fluid during general anesthesia is only a small fraction of that observed in conscious volunteers. Infusion of crystalloids during anesthesia shows reduced clearance and slower distribution such that intraoperative oliguria may not reflect fluid status or predict future AKI. Given that liberal fluid administration can be correlated with worse postoperative outcome, the recommendation to maintain urine output of at least 0.5 ml/kg/h should be considered.