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Intervertebral Disc Herniation clinical trials

View clinical trials related to Intervertebral Disc Herniation.

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NCT ID: NCT05296200 Completed - Clinical trials for Intervertebral Disc Herniation

Cervical Changes by 4h of Hyper-buoyancy Flotation and Followed by 15 Mins 1g Re-loading

Start date: March 13, 2020
Phase:
Study type: Observational

Study with the aim to see the effect on a space ground anaologue, Hyperbuoyancy Floatation (HBF) on cervical column.

NCT ID: NCT03340545 Completed - Clinical trials for Intervertebral Disc Herniation

MR Elastography for the Herniated Intervertebral Disc

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

Low back pain is a major cause of disability, especially in the working-age population. A total of 149 million working days are lost every year as a consequence of back pain. Intervertebral disc (IVD) degeneration is thought to play a major role in chronic back and neck pain. Decades of bench-top research in tissue mechanics have shown clear relationships between changes in mechanical properties and abnormal changes IVD structure and composition. Our overall hypothesis is that measurements of IVD mechanical properties can provide valuable information about its structure and composition for early diagnosis of degeneration, quantification of degeneration progress, and evaluation of treatment strategies. Magnetic Resonance Elastography (MRE) is an imaging method to quantify mechanical properties from soft tissues. The objectives of this study are to evaluating repeatability and collecting base line data from healthy individuals; and to apply MRE to patients with disc herniation.

NCT ID: NCT03158766 Completed - Infection Clinical Trials

Subclinical Propionibacterium Acnes Infection Estimation in the Intervertebral Disc (SPInE-ID)

SPInE-ID
Start date: May 31, 2017
Phase:
Study type: Observational

Subclinical infection of the intervertebral disc after lumbar disc herniation surgery has been correlated to chronic low back pain and vertebral endplate changes. The most commonly reported agent is Propionibacterium acnes. However, the real incidence is unclear, as it has been reported in some series ranging from 3.7% to 46%. Recently, a systematic review concluded that there is a relationship between P. acnes and endplate changes, but, there are so far no studies to verify whether the reported presence of that pathogen in the intervertebral discs is due to local infection or whether intraoperative contamination occurred during the collection of samples. Thus, the main objective of this study is to estimate the incidence of subclinical infection in patients surgically treated for lumbar disc herniation. To this end, a prospective cohort study will be conducted with a minimum of 95 patients between 18 and 65 years of age who have been submitted to surgery after failure of conservative treatment. The extruded disc will be removed and cultured for bacterial identification. As controls, the ligamentum flavum and the multifidus muscle, taken respectively before and after removal of the herniated fragment will also be cultured. Patients will be followed-up for a year and MRI will be done at the end of this period.

NCT ID: NCT02742311 Completed - Back Pain Clinical Trials

EuroPainClinics® Study V (Prospective Observational Study)

EPCSV
Start date: December 31, 2021
Phase: N/A
Study type: Interventional

In this prospective observational trial the effect of the Endoscopic discectomy microinvasive therapy should be examined in (approximately 500) adult patients with low back pain.