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Intellectual Disability clinical trials

View clinical trials related to Intellectual Disability.

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NCT ID: NCT05822596 Completed - Clinical trials for Intellectual Disability

Tablet-based Interactive Games in Elderly With Cognitive Impairment and Persons With Intellectual Disability

Start date: June 12, 2023
Phase: N/A
Study type: Interventional

The study has 10 research questions regarding the cognitive training program and tablet-based interactive games: Primary study questions: 1. Can the participation of 12-week cognitive training program using tablet-based interactive games maintain cognitive functioning? Secondary study questions: 2. Can the participation of 12-week cognitive training program using tablet-based interactive games improve the scores of 6 supplier-developed cognitive domains (including executive function, memory, eye-hand coordination, attention, visual-spatial ability, language)? 3. Can the participation of 12-week cognitive training program using tablet-based interactive games improve the reaction time of the participants? 4. What is the attendance rate in the cognitive training program, and for how long do the participants play the tablet-based interactive games? 5. What is the usability and acceptability of the tablet-based interactive games? Auxiliary study questions: 6. Can the participation of 12-week cognitive training program using tablet-based interactive games reduce neuropsychiatric symptoms? 7. Can the participation of 12-week cognitive training program using tablet-based interactive games improve upper-body flexibility? 8. What are the physical side effects of using digital devices in the 12-week cognitive training program? 9. What are the perceived benefits and feasibility of the cognitive training program and tablet-based interactive games? 10. Can the participation of 12-week cognitive training program using tablet-based interactive games improve activities of daily living of persons with intellectual disability?

NCT ID: NCT05785702 Recruiting - Technology Clinical Trials

Anti-wandering System for People With Intellectual Disability

Start date: September 25, 2023
Phase: N/A
Study type: Interventional

The study has 6 research questions regarding the use of the anti-wandering system in day activity centre cum hostel for persons with intellectual disabilities: Primary study questions: 1. Can the anti-wandering system reduce the time in seconds to turn off the alarm made by the system (a proxy measure of the response time of care staff)? 2. Can the anti-wandering system reduce the burden of care staff on keeping track of the residents? Secondary study questions: 3. How many alarms does the anti-wandering system generate? 4. How many false alarms does the anti-wandering system made as reported by staff? Auxiliary study questions: 5. What are the reasons for keeping or loosening restrictions on users due to the use of the anti-wandering system? 6. What are the perceived benefits and feasibility of anti-wandering system compared to conventional anti-wandering practices?

NCT ID: NCT05767203 Recruiting - Down Syndrome Clinical Trials

Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin

BioJeL
Start date: September 1, 2022
Phase: N/A
Study type: Interventional

Analyze genetic and biological markers in patients with Intellectual Deficiencies (ID) of genetic origin in order to better understand the mechanisms of modified genes, cellular mechanisms, pathways involved in different disorders , complications and pathologies associated with ID of genetic origin.

NCT ID: NCT05751525 Recruiting - Epilepsy Clinical Trials

Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome

iDEND
Start date: July 1, 2016
Phase:
Study type: Observational

The goal of this observational study is to learn about the impact of the diabetes drug glibenclamide (glyburide) on neurodevelopment in individuals with iDEND (developmental delay, epilepsy and neonatal diabetes) due to the V59M mutation in the KCNJ11 gene. The main question it aims to answer is whether initiating sulphonylurea (SU) therapy in the first year of life results in better neurodevelopmental outcomes in affected individuals, in comparison to starting therapy later than 12 months of age. Participants will undergo a neurodevelopmental assessment comprising parental and teacher completion of standardised questionnaires, and where possible face to face neuropsychological testing. Researchers will compare the outcomes of these standardised tests in the individuals who started SU therapy <12 months of age in comparison to those who started >12 months of age.

NCT ID: NCT05749419 Recruiting - Clinical trials for Congenital Disorders

Vaccinations and People With Disabilities

Start date: July 1, 2023
Phase:
Study type: Observational

The goal of this observational study is to learn about vaccinations hesitancy, delay or avoidance in children with chronic diseases, congenital anomalies or disabilities. The main questions it aims to answer are: • Attitudes of caregivers towards vaccinating their children, obstacles that postpone vaccinations, and the status of vaccinations of these children. Participants will fill out questionnaires and some will be included in focused groups for the qualitative part of the study. Researchers will compare the vaccinations status of the research group to their siblings' status as well as the published national records of vaccination compliance.

NCT ID: NCT05744479 Recruiting - Obesity Clinical Trials

Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability

METIDD
Start date: February 28, 2023
Phase: Phase 4
Study type: Interventional

People with IDD (intellectual and developmental disability) have very high rates of obesity and die prematurely from cardiometabolic disease. While antipsychotics contribute to this problem, their use is necessary and appropriate in a significant subgroup of individuals with IDD. Exercise and diet interventions have limitations and may not be sufficient, requiring effective adjunctive pharmacological approaches to target obesity and related comorbidities in IDD. However, persons with IDD treated with antipsychotics are systematically excluded from clinical trials hindering development of evidence to help guide safe and effective treatment of these comorbidities. Moreover, evidence from other disorders cannot be extrapolated to IDD given inherent biological differences between disorders. This trial will address the identified gaps, which extend beyond cardiovascular morbidity and negatively impact psychosocial outcomes, in a hugely underserviced population.This is the the first RCT (randomized control trial) to examine the efficacy of metformin in overweight or obese adults with IDD who have experienced antipsychotic-induced weight gain. By generating efficacy data for a very accessible and scalable intervention, allows for guideline and implementation strategies to address a recalcitrant health problem.

NCT ID: NCT05743439 Recruiting - Clinical trials for Intellectual Disability

Early Augmentative and Alternative Communication (AAC) Intervention Delivered Via Hybrid Telehealth

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The goal of this mixed methods study aims to develop and pilot test an augmentative and alternative communication (AAC) intervention for toddlers with intellectual and developmental disabilities (IDD) and their families. The main question it aims to answer is: Will this AAC intervention improve caregivers' use of naturalistic AAC intervention strategies, leading to increases in children's communication? The investigators will employ qualitative methods to conduct interviews to determine caregiver and speech-language pathologist preferences regarding an AAC intervention. Findings from these interviews will inform the adaptation of the AAC intervention procedures, service delivery approach, and strategies to increase caregiver's treatment adherence. Next, the researchers will conduct six multiple baseline designs across behaviors (AAC strategies) to develop the AAC intervention and demonstrate preliminary efficacy when delivered to families in-person. Caregiver-child dyads will receive 24 in-person intervention sessions during which the therapist will provide AAC instruction and coaching on using AAC strategies to caregivers. Last, the investigators will pilot test the AAC intervention using a hybrid telehealth model with nine caregiver-child dyads. Caregiver-child dyads will receive 24 intervention sessions, eight sessions provided to families in-person, and 16 sessions provided to families via telehealth. Our long-term goal is to develop a socially valid and effective intervention to improve language outcomes for toddlers with IDD. The researchers propose developing and pilot testing a hybrid telehealth AAC intervention for toddlers with IDD and their families. Researchers employ an implementation science approach, using systematic qualitative methods to identify caregivers' preferences and single-case experimental design methods to assess the feasibility of the AAC intervention. The central hypothesis is that the intervention will improve caregivers' use of naturalistic AAC intervention strategies, leading to increases in children's communication.

NCT ID: NCT05738278 Recruiting - Clinical trials for Autism Spectrum Disorder

Heart Rate Informed Changes in Care for Non-Communicating Patients

Start date: February 27, 2023
Phase: N/A
Study type: Interventional

The overarching aim is to generate knowledge to reduce incidence of pain in non-verbal patients' everyday life. The trial will 1) evaluate how HR can be used to identify potentially painful care procedures that should be re-evaluated in terms of the approach taken; 2) test the effect of heart rate (HR)-informed changes in potentially painful care procedures on biomarkers of pain, and 3) assess how six weeks of communication through HR affects the quality of communication between patient and caregiver.

NCT ID: NCT05727293 Completed - Sepsis Bacterial Clinical Trials

A Case Report of a Patient With Intellectual Disability and Neurogenic Bladder Complicated With Sepsis

Start date: September 6, 2022
Phase:
Study type: Observational

A case report of a patient with intellectual disability and neurogenic bladder complicated with sepsis

NCT ID: NCT05709405 Active, not recruiting - Clinical trials for Intellectual Disabilities

Reading Intervention for Children With Intellectual Disabilities Who Require Augmentative and Alternative Communication

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

The goal of this multiple single case study with multiple randomized baseline (with four starting points and 18 measurements across time) is to conduct a reading intervention for 40 children with intellectual disabilities who require augmentative and alternative communication (AAC). The main questions to answer are: 1. Is there a functional relation between the use of "Lesing for alle" (Reading for all) and increased accuracy of sound blending by students age 6-14 with intellectual disabilities who require AAC? 2. Is there a functional relation between the use of "Lesing for alle" (Lesing for alle) and improved acquisition of letter sound correspondence by students age 6-14 with intellectual disabilities who require AAC? 3. Is there a functional relation between the use of "Lesing for alle" (Reading for all) and improved acquisition of phoneme segmentation by students age 6-14 with intellectual disabilities who require AAC? 4. Is there a functional relation between the use of "Lesing for alle" (Reading for all) and improved acquisition of recognition of sight words by students age 6-14 with intellectual disabilities who require AAC? 5. Is there a functional relation between the use of "Lesing for alle" (Reading for all) and improved acquisition of decoding by students age 6-14 with intellectual disabilities who require AAC? 6. Is there a positive and strong correlation between increasing skills from 1-3 and 4-5? Meaning, is there a transfer from lower level skills (phonological skills) to decoding skills? The participants (age 6-14) will receive daily instruction in a reading material that follows all the strategies of Accessible Literacy Learning, developed by Janice Light and David McNaughton. It is the teachers who will carry out the teaching in the students fixed and familiar place at school. The reading material consist of tasks in sound blending, letter-sound correspondence, phoneme segmentation, sight words and decoding. The reading material will use explicit instruction, distributed and cumulative practice, and immediate and corrective feedback. The intervention will take place for a total of 18 months.