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Down Syndrome clinical trials

View clinical trials related to Down Syndrome.

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NCT ID: NCT05144373 Not yet recruiting - Down Syndrome Clinical Trials

Role of Early Motor Experience in Infants With Down Syndrome

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

Infants with Down syndrome show significant delays and weaknesses in motor, cognitive, and language development compared to typically developing infants. This project aims to examine the developmental cascade effects of specific gross and fine motor experience on motor, cognitive and language development in infants with Down syndrome. We propose that both gross and fine motor experience will facilitate cognitive and language development in infants with Down syndrome, and particularly, fine motor experience will help advance gesture and early words production.

NCT ID: NCT05131542 Active, not recruiting - Down Syndrome Clinical Trials

Assessment of Hypotonia in Children With Down Syndrome

Start date: April 1, 2019
Phase:
Study type: Observational

Hypotonia is a common trait in infants with Down syndrome, resulting in pathologies and delays in gaining basic motor skills. There are no screenings available to aid in early diagnosis, therefore, the purpose of this study is to develop a way to test for hypotonia in children with Down syndrome.

NCT ID: NCT05120531 Not yet recruiting - Down Syndrome Clinical Trials

Down Syndrome Autonomic Nervous System Induction Bradycardia

DANSIB
Start date: November 2021
Phase:
Study type: Observational

Children with Down syndrome (DS) often experience dangerously low heart rates on induction of anesthesia for routine procedures and this occurs at 10 times the rate of non-DS patients. Given that the cardiac output of children is heart rate dependent, bradycardia is especially perilous in this population. Historically, individuals with DS were not expected to survive beyond childhood; consequently, correction of congenital anomalies, e.g. cardiac defects, was not frequently offered. Fortunately, today individuals with DS live into adulthood and surgical correction of anomalies is universally offered. Thus, increasing numbers of children with DS are exposed to anesthesia and at risk for this hemodynamic catastrophe. It is medically unacceptable and an autonomic nervous system mechanism will be sought.

NCT ID: NCT05098600 Active, not recruiting - Clinical trials for Rheumatoid Arthritis

The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic

Start date: October 15, 2021
Phase:
Study type: Observational

The study series consists of two studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the registry of a dermatology clinic of a metropolitan hospital.

NCT ID: NCT05068570 Active, not recruiting - Clinical trials for EFFECT OF ARM ERGOMETRY ON RESPIRATION

Effect of Arm Ergometry on Children With Down Syndrome

Start date: June 1, 2021
Phase: N/A
Study type: Interventional

Cardiopulmonary issues are the major cause of sickness and hospitalisation in children with Down syndrome . Down syndrome children are also more likely to develop chronic lung infections, middle ear infections, and persistent tonsillitis.

NCT ID: NCT05059041 Not yet recruiting - Down Syndrome Clinical Trials

Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome

Start date: October 2021
Phase: Phase 2
Study type: Interventional

Individuals with Down syndrome (DS) live with visual deficits due, in part, to elevated levels of higher-order optical aberrations (HOA). HOAs are distortions/abnormalities in the structure of the refractive components of the eye (i.e. the cornea and the lens) that, if present, can result in poor quality focus on the retina, thus negatively impacting vision. HOAs in the general population are overall low, and thus not ordinarily considered during the eye examination and determination of refractive correction. However, for some populations, such as individuals with DS, HOAs are elevated, and thus the commonly used clinical techniques to determine refractive corrections may fall short. The most common clinical technique for refractive correction determination is subjective refraction whereby a clinician asks the patient to compare different lens options and select the lens that provides the best visual outcome. Given the cognitive demands of the standard subjective refraction technique, clinicians rely on objective clinical techniques to prescribe optical corrections for individuals with DS. This is problematic, because it may result in errors for eyes with elevated HOA given that these techniques do not include measurement of the HOAs. The proposed research evaluates the use of objective wavefront measurements that quantify the HOAs of the eye as a basis for refractive correction determination for patients with DS. The specific aim is to determine whether dilation of the eyes is needed prior to objective wavefront measurements. Dilation of the eyes increases the ability to measure the optical quality of the eye and paralyzes accommodation (the natural focusing mechanism of the eye), which could be beneficial in determining refractions. However, the use of dilation lengthens the process for determining prescriptions and may be less desirable for patients.

NCT ID: NCT05056285 Not yet recruiting - Growth Disorders Clinical Trials

Pattern of Growth and Characteristics of Down Syndrome Pediatrics Patients

Start date: October 1, 2021
Phase:
Study type: Observational [Patient Registry]

Down syndrome or Down's syndrome (DS), also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45 .

NCT ID: NCT05024110 Completed - Clinical trials for Vitamin D Deficiency

Effect of Exercise Intensity on Vitamin D

Start date: January 25, 2021
Phase: N/A
Study type: Interventional

Children with Down's syndrome (DS) are more liable to vitamin D deficiency. Treating this deficiency with supplements is associated with the risk of intoxication due to increased intestinal absorption or decreased vitamin D metabolism. The aim of the study was to compare the effect of two exercise intensities on the modulation of vitamin D and Parathormone (PTH) levels in children with DS.

NCT ID: NCT05020366 Recruiting - Down Syndrome Clinical Trials

Preventing Obesity Through Parent Empowerment and the Activation of Routines (PrO-PEAR)

PrO-PEAR
Start date: October 4, 2021
Phase: N/A
Study type: Interventional

This study will examine the feasibility of the Preventing Obesity through Parent Empowerment and the Activation of Routines (PrO-PEAR) intervention using a open case-series for intervention optimization followed by a pilot RCT in which participants are randomized to receive PrO-PEAR or enhanced usual care (EUC). Specific aims include: 1. Optimize the PrO-PEAR intervention manual using an open case series with iterative stakeholder feedback. 2. To determine the feasibility of the PrO-PEAR intervention in terms of recruitment, randomization, retention, adherence, and acceptability. 3. Estimate the effects of the PrO-PEAR intervention on parent reported child health behaviors in each Institute of Medicine obesity prevention area (nutrition, physical activity, sedentary behavior, sleep) over time as compared to a control group. The following benchmarks will be used to determine feasibility: Recruitment: >3 parent/child dyads per month Retention: >75% of consented dyads will complete > 8 sessions Adherence: >80% clinician protocol adherence during 100% of sampled sessions Data Collection: >80% planned assessments collected among intervention completers. Acceptability: >90% of parent intervention completers rate intervention as acceptable. Additionally, it is predicted that parents will report greater gains in the areas of nutrition, sleep, sedentary behavior and physical activity in the PrO-PEAR group than those in the control group.

NCT ID: NCT05016037 Not yet recruiting - Clinical trials for Speech Intelligibility Intervention in Down Syndrome

Predictors of Speech Ability in Down Syndrome

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Speech is a critical aspect of the human experience and usually develops in a "seemingly automatic process that continues from birth through adolescence and underlies many related abilities" (e.g., language and reading, see National Academy of Medicine Report on Speech and Language Disorders, 2016). Many individuals with Down Syndrome (Trisomy 21, DS) struggle to communicate and participate more fully in human communication and educational learning experiences because their speech is difficult to understand. The purpose of the proposed project is to measure speech-articulation accuracy and speech intelligibility, and their proposed primary predictors at study entry in 20 children with DS age 6;0 to 13;11). A validated treatment, speech recast intervention (see Yoder, Camarata & Woynaroski, 2016) will be used to drive growth in speech intelligibility as a means of evaluating changes in potential sequelae of change. This integrated study will include measures of speech-articulation accuracy, speech-prosody, general cognitive ability, receptive vocabulary skills, and clinical assay of oral-motor ability as potential predictors of speech intelligibility growth in DS. The Investigators will also be measuring suprasegmental and rhythmic factors associated with growth.