Night Time Walking to Improve Glycaemic Control in Healthy Adults

Insulin Resistance Clinical Trial

Official title:

The Effect of Exercise Timing on Postprandial Glycaemic Control: A Randomised Crossover Trial in Healthy Adults

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04958317
• Other study ID #: Night Glucose response-walk
• Status: Not yet recruiting
• Phase: N/A
• Start date: July 2021
• Est. completion date: November 2021

Study information

• Verified date: July 2021
• Source: Monash University
• Contact: Maxine Bonham, PhD
• Phone: +61418234292
• Email: maxine.bonham[@]monash.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Randomised crossover trial to compare early vs late walking on postprandial glycaemic response at night time.

Description:

In this crossover trial, eligible participants will be randomised to a 30-minute bout of physical activity (30 minute walk) either during the day or after an evening meal. The postprandial response to the evening meal will be analysed.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 12
• Est. completion date: November 2021
• Est. primary completion date: November 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion criteria

• Men and Women aged 18 to 65 years of age

• Waist circumference of <94cm and <80cm for Caucasian males and females, respectively

• Waist circumference of <90cm and <80 cm for Asian males and females, respectively

• Willingness to provide written informed consent and willingness to participate and comply with the study

Exclusion criteria

• Current or recent treatment (within 6 months) with medications that influence blood glucose

• Fasting blood glucose = 7 mmol/L

• Individuals diagnosed with type 1 or type 2 diabetes mellitus, chronic gastrointestinal disorders (including inflammatory bowel disease and celiac) or any other condition deemed unstable

• Serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery

• Not able to walk for 30 mins at 5-5.5 km/hr

• Women planning pregnancy, pregnant or lactating.

Related Conditions & MeSH terms

• Hyperglycemia
• Insulin Resistance
• Postprandial Hyperglycemia

Intervention

Other:
• Early exercise
Participants will exercise for 30 minutes prior to an evening meal.
• Late exercise
Participants will exercise for 30 minutes after an evening meal.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Monash University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postprandial glucose	Change in glucose incremental area under the curve (iAUC) in response to a meal challenge	Three hour glucose iAUC will be calculated at nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.
Secondary	Postprandial insulin	Change in insulin incremental area under the curve (iAUC) in response to a meal challenge	Three hour insulin iAUC will be calculated at six time points (0, 30, 60, 90, 120 and 180 mins) after beginning consumption of the test meal.