Insulin Resistance Clinical Trial
Official title:
Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development
This study includes 2 phases. During phase 1, pregnant women are followed over the course of
pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3 and 5 year after
delivery.
The purpose of this phase 1 is to :
- assess the contribution and interactions of adipokines in the development of insulin
resistance during pregnancy and gestational diabetes;
- assess levels of maternal adipokines as determinants of development and fetal growth;
- determine the genetic variations that influence levels of adipokines and glucose
regulation during pregnancy and in newborns.
The purpose of this phase 2 is to:
- identify DNA methylation variations at birth that are predictive of childhood
overweight/obesity.
- identify maternal characteristics associated with DNA methylation variations predictive
of childhood overweight/obesity.
- establish whether the loci predictive of childhood overweight/obesity at birth are
still differentially methylated at 5 years of age (samples collected at 5 years of
age).
- identify DNA methylation variations at birth that are predictive of childhood
neurodevelopment problems at 3 and 5 years of age.
n/a
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