Vapocoolant Spray Application During Intraarticular Knee Injection

Status Recruiting

Clinical Trial Summary

The goal of this observational study is to learn about the effects of vapocoolant spray applied during intraarticular knee injections on pain and anxiety compared to injections without any agent application in patients with knee osteoarthritis. The main questions it aims to answer are: • Contrary to popular belief, does coolant spray application really reduce pain? • Does it have an advantage over patients with placebo or no spray at all? After intraarticular knee hyaluronic acid application, patients will be asked to indicate injection-related pain and anxiety levels on a 100mm visual analog scale. Researchers will compare the patient groups who were applied coolant spray, placebo spray and injection without any spray.

Clinical Trial Description

Patients who underwent intra-knee hyaluronic acid injection due to knee degenerative diseases (osteoarthritis), meniscus and cartilage problems between October 2022 and December 2022 will be prospectively included in the study. Demographic characteristics of the patients (age, gender, body mass index), degree of knee degeneration, and past surgical procedures will be recorded. Before intra-articular injection can be given, one group will be sprayed with a vapocoolant, and one group will receive a placebo spray, while another group will receive no analgesic treatment while injection. Which patient will be evaluated in which group will be decided by randomization on the website www.random.org. 1 minute after the injection, the patients will be asked to indicate their pain level (1) and anxiety level (2) while inserting the needle on the 100mm Visual Analogue Scale (VAS). The same survey will be repeated after 10 minutes, and whether they are satisfied with the whole process will be measured with the same scale and the results will be recorded. The results will be compared between the groups, and the demographic characteristics of the patients, the level and types of disease, and the effects of vapocoolant spray application will be evaluated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05581433
Study type	Interventional
Source	Istanbul Rumeli University
Contact	Çagdas Pamuk, MD
Phone	+905058133336
Email	cagdaspamuk@hotmail.com
Status	Recruiting
Phase	N/A
Start date	October 20, 2022
Completion date	January 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04040985` - Legion Primary Safety and Efficacy	N/A
Active, not recruiting	`NCT04525950` - Robotized Navigation Compared to Conventional Technique in Total Knee Replacement	N/A
Recruiting	`NCT04320914` - High Intensity Laser Therapy (Classes IV) and Ibuprofen Gel Phonophoresis for Treating Knee Osteoarthritis	N/A
Completed	`NCT03886142` - Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis	N/A
Terminated	`NCT04072055` - MOTO Post-marketing Surveillance Study
Not yet recruiting	`NCT06385275` - The Role of Vitamin K on Knee Osteoarthritis Outcomes	Phase 1/Phase 2
Not yet recruiting	`NCT05290818` - Total Versus Robotic Assisted Unicompartmental Knee Replacement	N/A
Withdrawn	`NCT03271229` - Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee	Phase 2
Recruiting	`NCT05505552` - Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:	N/A
Recruiting	`NCT05992038` - Use of a Putty as Gap Filler in Open-wedge Osteotomy	N/A
Recruiting	`NCT06066684` - Pain Phenotyping in Knee OA: a Pilot Trial
Completed	`NCT03847324` - Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty	N/A
Recruiting	`NCT05126485` - Biofeedback Retention in Individuals With AKA	Early Phase 1
Completed	`NCT04956393` - The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study	N/A
Recruiting	`NCT04541342` - Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy	N/A
Completed	`NCT04391842` - Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis	Phase 1
Completed	`NCT03680807` - Power Production in Older Adults With Knee Osteoarthritis
Completed	`NCT03783455` - Effectiveness of Five Intraarticular Strategies on Knee Osteoarthritis	N/A
Not yet recruiting	`NCT06264362` - Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia	N/A
Completed	`NCT05089253` - Effect of Physical Therapy Modalities in Osteoarthritis	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.