Inhalation Injury Clinical Trial
Official title:
Selecting Specific Bio-markers and Researching Mechanisms of Immune Regulation From Inhalation Injury and Traumatic Lung Injury Based on Single Cell Sequencing Technology
Verified date | December 2022 |
Source | Changhai Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The goal of this observational study is to profile the circulating immunological traits of patients with traumatic lung injury (TLI) and inhalation injury (ILI),providing a new direction for the depth research of the pathogenesis, and providing new immune-related targets for diagnosis of the severity of lung injury and treatment. The investigators performed scRNA-seq of neutrophil and peripheral blood mononuclear cells (PBMCs) from 10 ml fresh circulating blood from 3 patients with TLI and 3 patients with ILI at longitudinal timepoints,as well as peripheral blood from 3 health controls(HCs).
Status | Completed |
Enrollment | 21 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility | Inclusion Criteria: 1. Lung injury caused by burn trauma is confirmed, and the patient is hospitalized within 24 hours after burn or trauma (the clinician can make a definite diagnosis of lung injury based on the comprehensive judgment of the patient's etiology, history, clinical manifestations, blood gas analysis, laboratory tests and imaging); 2. Patients with inhalation injury caused by head, face and neck burns or inhalation injury combined with multiple body burns < 30%; 3. Patients with simple inhalation injury; 4. The normal control group should have no smoking history and be normal population; 5. According to the provisions of Good Clinical Practice(GCP), the informed consent has been obtained and the informed consent has been signed to volunteer for the test. Exclusion Criteria: 1. Basic pulmonary diseases like chronic obstructive pulmonary disease (COPD), asthma and et al; 2. Severe organ dysfunction; 3. Autoimmune diseases; 4. Tumor; 5. Severe infection; 6. Pregnant or nursing women; 7. Fatal or life-threatening events caused by trauma; 8. Any history which may interfere the results or increase the risk of patients judged by researchers. |
Country | Name | City | State |
---|---|---|---|
China | Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University | ShangHai | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Changhai Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Computerized tomography, CT | according to the proportion of rib fracture, pneumothorax, hemothorax,lung contusion in the image | 1day | |
Primary | Computerized tomography, CT | according to the proportion of rib fracture, pneumothorax, hemothorax,lung contusion in the image | 3 day | |
Primary | Computerized tomography, CT | according to the proportion of rib fracture, pneumothorax, hemothorax,lung contusion in the image | through study completion, an average of 2 weeks | |
Primary | Partial pressure of carbon dioxide in arterial blood, PaCO2 | 1day | ||
Primary | Partial pressure of carbon dioxide in arterial blood, PaCO2 | 3 day | ||
Primary | Partial pressure of carbon dioxide in arterial blood, PaCO2 | through study completion, an average of 2 weeks | ||
Primary | Oxygenation index and Fraction of Inspired Oxygen will be combined to report FiO2/PaO2 | 1 day | ||
Primary | Oxygenation index and Fraction of Inspired Oxygen will be combined to report FiO2/PaO2 | 3 day | ||
Primary | Oxygenation index and Fraction of Inspired Oxygen will be combined to report FiO2/PaO2 | through study completion, an average of 2 weeks |
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