Inhalation Injury Clinical Trial
Official title:
Selecting Specific Bio-markers and Researching Mechanisms of Immune Regulation From Inhalation Injury and Traumatic Lung Injury Based on Single Cell Sequencing Technology
The goal of this observational study is to profile the circulating immunological traits of patients with traumatic lung injury (TLI) and inhalation injury (ILI),providing a new direction for the depth research of the pathogenesis, and providing new immune-related targets for diagnosis of the severity of lung injury and treatment. The investigators performed scRNA-seq of neutrophil and peripheral blood mononuclear cells (PBMCs) from 10 ml fresh circulating blood from 3 patients with TLI and 3 patients with ILI at longitudinal timepoints,as well as peripheral blood from 3 health controls(HCs).
The investigators performed single-cell transcriptomic sequencing (BD Rhapsody) on neutrophil and PBMCs extracted from the fresh circulating blood from 3 patients with TLI and 3 patients with ILI at longitudinal timepoints,as well as peripheral blood from 3 health controls(HCs). Three time points are picked by clinical conditions of patients with TLI or ILI: day 1 post hospital admission, day 3 post hospital and the day before discharged which matched to acute stage,progressive stage and convalescence. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05886543 -
Pilates Exercise and Inhalation Injury Post Burn
|
N/A | |
| Terminated |
NCT01773083 -
Trial of Nebulized Heparin Versus Placebo for Inhalation Trauma
|
Phase 3 | |
| Completed |
NCT00997555 -
Prophylactic Bronchoscopy After Inhalation Injury in Burn Patients
|
N/A | |
| Completed |
NCT04125108 -
The Effect of a Pulmonary Rehabilitation on Lung Function and Exercise Capacity in Patients With Burn
|
N/A | |
| Recruiting |
NCT05190497 -
Effects of IMT on Pulmonary Functions IN CASES With Inhalation Injury
|
N/A | |
| Completed |
NCT01194024 -
Scoring System for Inhalation Injury
|
||
| Completed |
NCT04667676 -
Respiratory Functions Response To Tens Acupoint Stimulation Post Inhalation Injury
|
N/A | |
| Recruiting |
NCT05988294 -
Pilates Exercises in Patients With Inhalation Injury
|
N/A | |
| Recruiting |
NCT05915494 -
Intermittent-pneumatic Compression in Inhalation-injury Children: Effects on Diaphragm Mobility and Pulmonary Function
|
N/A | |
| Recruiting |
NCT06326593 -
Wii Aerobic Training in Inhalation-injury Children Post-thermal Burn
|
N/A | |
| Not yet recruiting |
NCT01287806 -
Ulinastatin in Inhalation Lung Injury
|
Phase 2 | |
| Completed |
NCT05705713 -
First-day Computed Tomography: Does it Has a Role in the Assessment of Patients With Inhalation Lung Injury?
|
N/A |