Influenza Clinical Trial
Official title:
The Role of Influenza as a Trigger for Acute Myocardial Infarction: a Self-controlled Case Series Analysis of Linked Data From the Myocardial Ischaemia National Audit Project (MINAP) and the General Practice Research Database (GPRD)
The purpose of this study is to examine the incidence of acute myocardial infarction (MI) occurring after an influenza-like illness using linked primary care and disease registry databases.
This study will measure the incidence ratio for MI occurring in time periods after
presentation with an acute respiratory illness compared to baseline time periods using the
self-controlled case series method, with reference to the timing of the influenza season
(defined by national virological and clinical surveillance data). It will also validate
accuracy and completeness of information on MI in the GPRD using linked anonymised data from
both MINAP and Hospital Episode Statistics.
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke
studies and electronic records) programme funded over 5 years from the NIHR and Wellcome
Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia
National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching
aim of CALIBER is to better understand the aetiology and prognosis of specific coronary
phenotypes across a range of causal domains, particularly where electronic records provide a
contribution beyond traditional studies. CALIBER has received both Ethics approval (ref
09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
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Time Perspective: Retrospective
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