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Influenza clinical trials

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NCT ID: NCT02154061 Completed - Influenza Clinical Trials

Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics

VAX-002
Start date: April 2015
Phase: N/A
Study type: Interventional

The purpose of the study is to better understand how the use of antibiotics changes micro-organisms in the intestines. The change to micro-organisms in the intestines may change the body's vaccine immune response and alter the effectiveness of the IIV (seasonal flu) vaccine. In particular, the investigators will be looking at certain markers in blood after vaccination with IIV (seasonal flu vaccine) with or without the use of antibiotics before vaccination. There will be two randomized groups. Group A will start taking antibiotic by mouth 3 days prior to vaccination and continue taking antibiotics the day of vaccination and one day after vaccination for a total of 5 days. Group B will only receive the IIV (seasonal flu vaccine) and will not take any antibiotics. The investigators hope to enroll 50 subjects at Emory.

NCT ID: NCT02151201 Completed - Influenza Clinical Trials

Impact of Influenza Vaccination in Pregnancy Video Education

Start date: November 2013
Phase: N/A
Study type: Interventional

We evaluated the impact of viewing an educational video about influenza vaccination in pregnancy just prior to a routine prenatal visit on vaccination health beliefs and vaccination rate. We hypothesized that the video would positively impact both vaccination health beliefs and vaccination rate compared to a control video.

NCT ID: NCT02148328 Completed - Influenza Clinical Trials

Safety, Tolerability, and Immunogenicity Study of a Cell-based Virosomal Influenza Vaccine in Healthy Adults

Start date: May 2014
Phase: Phase 1
Study type: Interventional

The purpose of this study is to examine the safety and tolerability after administration of trivalent and quadrivalent cell-based virosomal influenza vaccine in healthy adults.

NCT ID: NCT02148211 Completed - Influenza Clinical Trials

Fluarix/ FluLaval/ Fluarix Quadrivalent/ FluLaval Quadrivalent Vaccine Pregnancy Registry

Start date: June 1, 2014
Phase:
Study type: Observational

The purpose of this pregnancy registry study is to detect and describe abnormal pregnancy outcomes in women intentionally or unintentionally vaccinated with any of GlaxoSmithKline (GSK) Biologicals' seasonal Inactivated Influenza Vaccines (sIIVs): Fluarix, FluLaval, Fluarix Quadrivalent and FluLaval Quadrivalent.

NCT ID: NCT02141581 Completed - Influenza Clinical Trials

Plasmablast Trafficking and Antibody Response in Influenza Vaccination (SLVP021 2011-2014)

Start date: August 2011
Phase: Phase 4
Study type: Interventional

The purpose of this study is to investigate the responses to licensed trivalent, inactivated influenza vaccine (TIV) delivered by different routes: intramuscular (IM) and intradermal (ID) and to the live, attenuated influenza vaccine (LAIV) administered intranasally -- all given to generally healthy male and female adult volunteers.

NCT ID: NCT02136017 Completed - Influenza Clinical Trials

Post-License Safety Evaluation of Influenza Virus Vaccine

Start date: January 2013
Phase: N/A
Study type: Observational

To evaluate the safety of the post-licensed influenza virus vaccine made of Changchun Institute of Biological Products Co.,Ltd.

NCT ID: NCT02134184 Completed - Influenza Clinical Trials

The Influence of Chronic CMV Infection on Influenza Vaccine Responses

SLVP025
Start date: October 2012
Phase: Phase 4
Study type: Interventional

In this study we are trying to understand whether previous infection with a particular virus, namely cytomegalovirus (CMV), influences the ability of the immune system to respond to new infections or vaccinations with age.

NCT ID: NCT02133781 Completed - Influenza Clinical Trials

B-cell Immunity to Influenza (SLVP017)- Year 1, 2009

Start date: July 2009
Phase: Phase 4
Study type: Interventional

This is an exploratory study using a strategy that has not been previously employed to investigate the effects of age and vaccine type on specific kinds of immune responses to licensed, seasonal 2009-2010 influenza vaccines in children and adults.

NCT ID: NCT02133456 Completed - Influenza Clinical Trials

A Post-marketing Safety Study of Inactivated, Split-virion Influenza Vaccine in Subjects Aged 3 Years and Older

Start date: January 2014
Phase: N/A
Study type: Observational

To monitor the safety of Shanghai Institute of Biological Products Company's influenza vaccine in subjects aged 3 years and older through Adverse Events Following Immunization Surveillance System of China. The hypothesis is that there is no significant difference in the occurrence of adverse events among influenza vaccines manufactured by SIBP and other companies.

NCT ID: NCT02126761 Completed - Influenza Clinical Trials

Safety and Immunogenicity of Different Formulations of an Adjuvanted, Trivalent Subunit Influenza Vaccine in Elderly Subjects 65 Years of Age and Above

Start date: June 2014
Phase: Phase 1
Study type: Interventional

In this study, the safety and immunogenicity of the current formulation of aTIV will be compared to aTIV-modified formulations in which the dosage of the MF59 adjuvant will be doubled or tripled and/or the dosage of the 3 influenza virus strains will be doubled, in independently-living elderly subjects ≥ 65 years of age.