Inflammation Clinical Trial
Official title:
A Study of the Correlation Between Psychological Resilience and Genetic, Inflammatory Indicators in Young Population
The goal of this observational study is to evaluate and analyze the influencing factors of the adaptive ability of young people, explore the impact of the interaction of environment and gene on the psychological adaptive ability of young people, incorporate the prediction model of the dynamic change of adaptive ability, build a standardized norm of young people's adaptive ability, and form a grading reference standard system. The main questions it aims to answer are: - What are most important influencing factors for the adaptive ability of young people? - How the environment and gene interact with each other on the psychological adaptive ability of young people? - Can we build a prediction model of the dynamic change of adaptive ability and form a grading reference standard system? Participants will support us with basic information data, adaptive ability assessment data, genetic testing data, brain image scanning data, and inflammatory indicators data. Then subjects were divided into very low adaptive group, low adaptive group, high adaptive group and very high adaptive group according to the quartile of adaptive ability score. And the statistical analysis will be performed by the data analyst.
Status | Not yet recruiting |
Enrollment | 400 |
Est. completion date | December 31, 2024 |
Est. primary completion date | March 31, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 24 Years |
Eligibility | Inclusion Criteria: - Age 18-24 years old; high school graduation and above; agree to collect blood samples and sign an informed consent form. Exclusion Criteria: - Did not consent to the collection of blood samples; did not sign an informed consent form; suffered from a major illness such as a malignant tumor. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Qianfoshan Hospital |
Brunette MF, Erlich MD, Edwards ML, Adler DA, Berlant J, Dixon L, First MB, Oslin DW, Siris SG, Talley RM. Addressing the Increasing Mental Health Distress and Mental Illness Among Young Adults in the United States. J Nerv Ment Dis. 2023 Dec 1;211(12):961-967. doi: 10.1097/NMD.0000000000001734. — View Citation
Greenberg RL, Guzick AG, Schneider SC, Weinzimmer SA, Kook M, Perozo Garcia AB, Storch EA. Depressive Symptoms in Autistic Youth with Anxiety Disorders. J Dev Behav Pediatr. 2023 Dec 1;44(9):e597-e603. doi: 10.1097/DBP.0000000000001223. Epub 2023 Oct 11. — View Citation
Wong WLE, Arathimos R, Lewis CM, Young AH, Dawe GS. Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach. PLoS One. 2023 Nov 15;18(11):e0294045. doi: 10.1371/journal.pone.0294045. eCollection 2023. — View Citation
Type | Measure | Description | Time frame | Safety issue |
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Primary | the Assessment of the Psychological Resillience | Psychological Resillience was evaluated across multiple dimensions, including cognitive functioning, stress coping, psychological well-being, and personality traits, and was measured using internationally accepted scales. Psychological Resillience is measured using the Psychological Resilience Scale (CD-RISC), which consists of 25 items rated on a 5-point Richter's scale, with scores ranging from 0 to 4 indicating that this is not the case at all, seldom the case, sometimes the case, often the case, and almost always the case. The sum of the scores of the items is the total score of the scale, and the total score is 0~100, the larger the score indicates the higher the level of psychological resilience, and the score of less than 60 is the poor level of psychological resilience, 61~69 is the average level of psychological resilience, 70~79 is the good level of psychological resilience, and >=80 is the excellent level of psychological resilience. | 1 year |
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