Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05641584 |
Other study ID # |
2022/155 |
Secondary ID |
|
Status |
Completed |
Phase |
|
First received |
|
Last updated |
|
Start date |
May 10, 2022 |
Est. completion date |
July 10, 2022 |
Study information
Verified date |
December 2022 |
Source |
Bakirkoy Dr. Sadi Konuk Research and Training Hospital |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
In this study, the investigators aimed to determine whether the preoperative Monocyte/HDL
ratio would be a predictor of postoperative mortality and morbidity in patients who underwent
aortic valve replacement due to aortic stenosis.
Description:
Inflammation is causally associated with both coronary artery disease and aortic stenosis.
Although aortic stenosis is considered a static degenerative and calcific process, recent
evidence has shown the opposite. The role of inflammation in the pathogenesis of AS It will
be investigated that mortality may be associated with increased inflammation in patients
treated with AVR.
Adult patients (aged ≥18 years) with ASA II-IV who underwent elective aortic valve
replacement under cardiopulmonary bypass (CPB) due to aortic stenosis in our clinic between
January 1, 2010 and March 31, 2022, will be included in the study by retrospectively scanned
from the computer system and patient cards. The exclusion criteria from the study are as
follows; those with signs of acute infection, those with autoimmune disease, those with
severe renal (serum creatinine >2.0 mg/dl) disease, those with severe hepatic disease, those
with suspected malignancy.
Demographic characteristics of patients (age, gender, body mass index, diabetes mellitus,
hypertension, chronic kidney disease-failure, peripheral vascular disease, smoking history,
hyperlipidemia, atrial fibrillation history, left ventricular ejection fraction, coronary
artery disease history, Cabg history) Europe Cardiac Operative Risk Assessment System II
(EuroSCORE), Systemic Immune-Inflammatory Index (SII), APACHE II, SOFA Score, NYHA III/IV
values, drugs used (ASA, oral anticoagulants, beta blocker, statin, ACE inh., ARB) ,
preoperative glucose, HbA1c, urea, creatinine, total cholesterol, LDL, HDL, triglyceride,
hemoglobin, hematocrit, platelet, WBC, neutrophil, lymphocyte, monocytes, monocyte/HDL ratio,
CRP, preoperative and postoperative EF and PAB values, ICU admission duration, duration of
invasive mechanical ventilation, type of discharge, amount of ES replaced will be recorded.
Operation time, cardiopulmonary bypass (extracorporeal circulation) time, cross clamp time,
inotropic and vasopressor requirements will be recorded)