Comparison of CRP Levels, Neutrophil Count, & Clinical Outcomes of Low

Status Completed

Clinical Trial Summary

Clinical Trial Description

The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was found that nociception and proinflammatory cytokines play a joint regulatory role, i.e., increased production of proinflammatory cytokines can worsen the pain. Major surgery can trigger the release of cytokines such as IL-1, IL-6, and TNF-α. The acute analgesic effect of ketamine is generally believed to be mediated through the blockade of the phencyclidine binding site of the N-methyl-d-aspartate (NMDA) receptor of nociceptive neurons. Ketamine can reduce the inflammatory response marked by a decrease in CRP levels to surgical trauma and can prevent secondary damage to tissues/organs that were not initially affected by surgery by reducing inflammation. This also reduces postoperative pain and analgesics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04462094
Study type	Interventional
Source	Udayana University
Contact
Status	Completed
Phase	N/A
Start date	July 27, 2020
Completion date	November 10, 2020

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Comparison of CRP Levels, Neutrophil Count, and Clinical Outcomes of Low Dose Ketamine Between at Anesthesia Induction and at the End of Surgery in Patients Undergo Elective Laparotomy — PRO-Ketamine

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms