Induction of Gut Permeability by an Oral Vaccine

Status Active, not recruiting

Clinical Trial Summary

This study evaluates the effect of an oral typhoid vaccine on disruption of the intestinal barrier and response of the immune system. Intestinal and whole-body responses will be measured in all participants before and after the vaccine.

Clinical Trial Description

The licensed Ty21a vaccine strain of S. enterica Typhi is routinely used by travelers to countries where typhoid is common. It is not known whether the vaccine causes measurable changes in intestinal permeability and whether changes in permeability are correlated with the magnitude of the vaccine response. In the current study, gut permeability will be measured in participants at baseline and after an aspirin challenge, which is known to disrupt intestinal permeability, and after the first, second, and fourth doses of a the Ty21a vaccine. Intestinal permeability will be measured using a three-sugar absorption test composed of lactulose, mannitol, and sucralose and by several plasma markers. Vaccine response will be measured by quantitating T cells and newly developed IgG-or IgA-secreting plasma cells specific for Ty21a. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04083950
Study type	Interventional
Source	USDA, Western Human Nutrition Research Center
Contact
Status	Active, not recruiting
Phase	Early Phase 1
Start date	December 4, 2019
Completion date	September 30, 2024

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