Fibro-inflammatory Progression From Acute to Chronic Pancreatitis

Status Recruiting

Clinical Trial Summary

Observational prospective study evaluating the developement of chronic pancreatitis based on imaging modalities as well as biochemical markers of inflammation, fibrosis and oxidative stress.

Clinical Trial Description

Chronic pancreatitis (CP) represents the end-stage of a continuous disease process evolving from acute pancreatitis (AP), over recurrent acute pancreatitis (RAP). Due to the irreversible nature of CP, early detection and prevention is key. The study uses state-of-the-art imaging modalities as well as biochemical markers of to evaluate fibrosis progression in patients with pancreatitis.

The included participants have either first time AP, RAP, early CP with preserved pancreatic exocrine and endocrine function or end-stage CP with exocrine insufficiency. Included patients will be followed prospectively for 15 years with advanced MRI and contrast enhanced EUS with elastography, assessment of endocrine and exocrine pancreatic function, biochemical and nutritional assessment, and evaluation of pain processing using quantitative sensory testing. Blood for a biobank will be obtained. The purpose of the biobank is to allow analyses of potential biomarkers for the progression of disease eventually leading to CP. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03853447
Study type	Observational
Source	Copenhagen University Hospital, Hvidovre
Contact	Srdan Novovic, PhD
Phone	38623862
Email	srdan.novovic@regionh.dk
Status	Recruiting
Phase
Start date	February 14, 2019
Completion date	January 1, 2041

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