Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association

Inflammation Clinical Trial

Official title:

Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03622632
• Other study ID #: 263425
• Status: Active, not recruiting
• Start date: September 30, 2018
• Est. completion date: September 2020

Study information

• Verified date: February 2020
• Source: Hopital du Sacre-Coeur de Montreal
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this project, is to better understand the fluctuation of the level of uric acid in traumatized patients by making serial measurements during their hospitalization in the intensive care unit. In addition, the determinants (e.g. type of trauma, diseases, interventions) of the blood level of uric acid and its association with the development of organ failure will be sought.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 25
• Est. completion date: September 2020
• Est. primary completion date: August 2020
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Direct admission to trauma center

• = 3h after trauma

• ISS = 16

• Received at least 1L of fluid at ER entrance

Exclusion Criteria:

• Isolated head injury

• Isolated spine injury

• Chemotherapy within the last month

• Hematologic disease

• Chronic hemodialysis

• Uricase treatment within the last week

• Expected death within 48h

Related Conditions & MeSH terms

• Inflammation
• Trauma

Locations

Country	Name	City	State
Canada	Hôpital du Sacré-Cœur de Montréal	Montreal	Quebec

Sponsors (2)

Lead Sponsor	Collaborator
Hopital du Sacre-Coeur de Montreal	Fonds de la Recherche en Santé du Québec

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Feasibility of serial plasmatic uric acid sampling after trauma	Number of measures collected/number of measures planned	7 days
Secondary	Impact of resuscitation on uric acid measures	Impact of fluid administration (amount in mL) on the changes of subsequent uric acid blood level	24 to 48 hours
Secondary	Clinical predictors of the first blood uric acid (µmol/L) level measured	Impact of patient's characteristics and physiological variables on the first measured blood uric acid.; Characteristics will include: age (years), gender, Injury severity score, presence of acute renal impairment.; Physiological variables will include: lower systolic blood pressure, base deficit, lactate level	12 hours