Inflammation Clinical Trial
— SirTaMOfficial title:
The Relation Between Acute Changes in the Systemic Inflammatory Response, Thiamine and Magnesium Concentrations and Transketolase Activity After Elective Knee Arthroplasty.
Verified date | April 2020 |
Source | Glasgow Royal Infirmary |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
We wish to determine to what extent magnesium, thiamine and transketolase activity are
affected by the Systemic Inflammatory Response (SIR). The knee arthroplasty model affords the
ideal study design, as surgery generates an inflammatory response.
Blood samples are drawn preoperatively and for up to four days post operatively, and again at
three months post-operation.
Status | Completed |
Enrollment | 47 |
Est. completion date | June 1, 2019 |
Est. primary completion date | June 1, 2019 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility |
Inclusion Criteria: - undergoing elective total knee replacement Exclusion Criteria: - taking multivitamin |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Glasgow Royal Infirmary | Glasgow |
Lead Sponsor | Collaborator |
---|---|
Glasgow Royal Infirmary | NHS Greater Glasgow and Clyde |
United Kingdom,
Altura BM, Shah NC, Shah GJ, Zhang A, Li W, Zheng T, Perez-Albela JL, Altura BT. Short-term Mg deficiency upregulates protein kinase C isoforms in cardiovascular tissues and cells; relation to NF-kB, cytokines, ceramide salvage sphingolipid pathway and PKC-zeta: hypothesis and review. Int J Clin Exp Med. 2014 Jan 15;7(1):1-21. eCollection 2014. — View Citation
Crawford SO, Hoogeveen RC, Brancati FL, Astor BC, Ballantyne CM, Schmidt MI, Young JH. Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study. Int J Epidemiol. 2010 Dec;39(6):1647-55. doi: 10.1093/ije/dyq126. Epub 2010 Aug 25. — View Citation
Dibaba DT, Xun P, He K. Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review. Eur J Clin Nutr. 2015 Mar;69(3):409. doi: 10.1038/ejcn.2014.275. Epub 2015 Jan 7. — View Citation
Salih S, Sutton P. Obesity, knee osteoarthritis and knee arthroplasty: a review. BMC Sports Sci Med Rehabil. 2013 Dec 4;5(1):25. doi: 10.1186/2052-1847-5-25. — View Citation
Wolf E, Utech M, Stehle P, Büsing M, Stoffel-Wagner B, Ellinger S. Preoperative micronutrient status in morbidly obese patients before undergoing bariatric surgery: results of a cross-sectional study. Surg Obes Relat Dis. 2015 Sep-Oct;11(5):1157-63. doi: 10.1016/j.soard.2015.03.018. Epub 2015 Apr 2. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Iron receptor status | blood sample | three months | |
Primary | serum magnesium | blood sample | three months | |
Primary | thiamine | blood sample | three months | |
Primary | erythrocyte transketolase activity | blood sample | three months |
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