Inflammation Clinical Trial
Verified date | March 2018 |
Source | Nicolaus Copernicus University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The research aims to determine the impact of 30-day supplementation of melatonin on the antioxidative defense mechanisms and the release of markers of oxidative stress and inflammation in rowers and footballers undergoing training of submaximal intensity.
Status | Completed |
Enrollment | 81 |
Est. completion date | December 31, 2012 |
Est. primary completion date | December 31, 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - sign informed consent form for participation in the study Exclusion Criteria: - diseases - the participants will not be minor and incapacitated persons, soldiers, prisoners and persons dependent in any way from the investigators |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Nicolaus Copernicus University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Measurement of oxidative stress parameters and inflammatory markers concentration before melatonin administration, at baseline. | The study was conducted in football players and rowers and the control group. Samples of blood from the basilic vein were taken once, from both the control group and the athletes at baseline. In blood serum, the ELISA method was used to determine the concentrations of melatonin, isoprostanes (8-iso-PGF2a), anti-ox-LDL antibodies, interleukin-6 and C-reactive protein (CRP). In red blood cells, the concentration of reduced glutathione (GSH), thiobarbituric acid reactive substances (malondialdehyde, MDA) were determined and the activity of glutathione peroxidase (GSH-Px), cytoplasmic superoxide dismutase (SOD-1) and glutathione reductase (GR) were determined. | 1 day | |
Secondary | Changes in oxidative stress parameters and inflammatory markers concentration afer 30 days of melatonin administration in athletes. | After 30 days of melatonin supplementation, samples of blood from the basilic vein were taken only from athletes, once, in the same day. In biochemistry laboratory, in blood serum, the ELISA method was used to determine the concentrations of melatonin, isoprostanes (8-iso-PGF2a), anti-ox-LDL antibodies, interleukin-6 and C-reactive protein (CRP). In red blood cells, the concentration of reduced glutathione (GSH), thiobarbituric acid reactive substances (malondialdehyde, MDA) were determined and the activity of glutathione peroxidase (GSH-Px), cytoplasmic superoxide dismutase (SOD-1) and glutathione reductase (GR) were determined. | 30 day |
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