Inflammation Clinical Trial
Official title:
Influence of Bananas Varying in Carbohydrate and Phenolic Content on Exercise Performance and Recovery
Verified date | January 2016 |
Source | Appalachian State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In a previous study at the Appalachian State University (ASU) Human Performance Laboratory
at the North Carolina Research Campus (NCRC), investigators showed that cyclists ingesting
about one-half of a banana with water every 15 minutes cycled 75-km faster (5%) than with
water alone. The polyphenols (i.e., chemicals in plants with health benefits) in the banana
improved the capacity to counter oxidative stress, and the sugars lowered post-exercise
inflammation. The cyclists reported some gastrointestinal discomfort, however, from the high
volume of bananas consumed. Dole Foods, the sponsor of this study, has a banana collection
that includes many different varieties, including the Mini banana that has a higher sugar
(50%) and phenolic (63%) content than the typical banana (Cavendish) available in stores.
Thus athletes should experience similar performance benefits from a smaller volume of Mini
compared to Cavendish bananas, and reduced gastrointestinal symptoms. If study results are
favorable, Dole Foods may market the Mini banana as the "sport" banana.
The purpose of this study is to compare ingestion of Mini and Cavendish bananas with an
equicaloric, sugar-only beverage or water on 75-km cycling performance and post-exercise
oxidative capacity and stress, inflammation, immune function, muscle damage and soreness,
and gastrointestinal symptoms.
Status | Completed |
Enrollment | 23 |
Est. completion date | January 25, 2017 |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 55 Years |
Eligibility |
Inclusion Criteria: - Healthy, with no known cardiovascular disease, diabetes, or cancer. - Non-smoker. - Regularly compete in road races (category 1 to 5) and/or capable of cycling 75 km in a laboratory setting (using own bicycles on CompuTrainer training systems). - Agree to train normally, maintain weight, and avoid the regular use of large-dose vitamin and mineral supplements, herbs, and medications that influence inflammation and immune function (in particular, Advil, Motrin, aspirin and similar anti-inflammatory drugs) for the duration of the 7 to 8-week study. If in doubt, discuss supplement/medication use with the Research Manager. - Categorized as "low risk" using the American College of Sports Medicine screening questionnaire. Exclusion Criteria: - Inability to comply with study requirements. - Any other concurrent condition which, in the opinion of the primary investigator (PI), would preclude participation in this study or interfere with compliance. - Current diagnosis of cardiovascular disease, diabetes, or cancer (except for non-melanoma skin cancer). |
Country | Name | City | State |
---|---|---|---|
United States | Human Performance Lab, North Carolina Research Campus | Kannapolis | North Carolina |
Lead Sponsor | Collaborator |
---|---|
Appalachian State University | Dole Food Company |
United States,
Nieman DC, Gillitt ND, Sha W, Meaney MP, John C, Pappan KL, Kinchen JM. Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery. J Proteome Res. 2015 Dec 4;14(12):5367-77. doi: 10.1021/acs.jproteome.5b00909. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in total plasma concentrations of inflammatory cytokines | Total plasma concentrations of five inflammatory cytokines [monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNFa), IL-6, IL-8, and IL-10] will be determined using an electrochemiluminescence based solid-phase sandwich immunoassay (Meso Scale Discovery, Gaithersburg,MD, USA). | Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours) | |
Secondary | Change in concentration of serum myoglobin | muscle damage marker | Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours) | |
Secondary | Change in muscle concentration of glycogen | change in muscle glycogen using ultrasound | Pre-exercise, and post-exercise (0 hours) | |
Secondary | Change in self-reported gastrointestinal and mental symptoms from a short questionnaire | Gastrointestinal and mental symptoms, 1-12 Likert scale | Pre-exercise, and post-exercise (0 hours) | |
Secondary | Change in concentration of ferric reducing ability of plasma (FRAP) | total plasma antioxidant power | Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours) | |
Secondary | Change in plasma concentration of oxidized low density lipoprotein | oxidative stress | Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours) | |
Secondary | Change in blood natural killer cell activity | innate immune measure | Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours) |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03995979 -
Inflammation and Protein Restriction
|
N/A | |
Completed |
NCT03255187 -
Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution
|
N/A | |
Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
Completed |
NCT03577223 -
Egg Effects on the Immunomodulatory Properties of HDL
|
N/A | |
Completed |
NCT04383561 -
Relationship Between LRG and Periodontal Disease
|
N/A | |
Active, not recruiting |
NCT03622632 -
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
|
||
Completed |
NCT06216015 -
Exercise Training and Kidney Transplantation
|
N/A | |
Completed |
NCT04856748 -
Nomogram to Diagnose Prostatic Inflammation (PIN) in Men With Lower Urinary Tract Symptoms
|
||
Completed |
NCT05529693 -
Efficacy of a Probiotic Strain on Level of Markers of Inflammation in an Elderly Population
|
N/A | |
Recruiting |
NCT05670301 -
Flemish Joint Effort for Biomarker pRofiling in Inflammatory Systemic Diseases
|
N/A | |
Recruiting |
NCT05415397 -
Treating Immuno-metabolic Depression With Anti-inflammatory Drugs
|
Phase 3 | |
Recruiting |
NCT05775731 -
Markers of Inflammation and of the Pro-thrombotic State in Hospital Shift and Day Workers
|
||
Recruiting |
NCT04543877 -
WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study
|
Early Phase 1 | |
Completed |
NCT03859934 -
Metabolic Effects of Melatonin Treatment
|
Phase 1 | |
Completed |
NCT03429920 -
Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
|
N/A | |
Completed |
NCT06065241 -
Quantifiably Determine if the Botanical Formulation, LLP-01, Has a Significant Clinical Effect on Proteomic Inflammatory Biomarkers and Epigenetic Changes in Healthy, Older Individuals.
|
N/A | |
Active, not recruiting |
NCT05864352 -
The Role of Dietary Titanium Dioxide on the Human Gut Microbiome and Health
|
||
Completed |
NCT03318731 -
Efficacy and Safety of Fenugreek Extract on Markers of Muscle Damage and Inflammation in Untrained Males
|
N/A | |
Not yet recruiting |
NCT06134076 -
Comparing Effects of Fermented and Unfermented Pulses and Gut Microbiota
|
N/A | |
Not yet recruiting |
NCT06159543 -
The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes
|
N/A |