Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease

Inflammation Clinical Trial

Official title:

The Levels of Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Gingival Crevicular Fluid in Periodontal Disease and Health

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02848378
• Other study ID #: 2014/17
• Status: Completed
• Phase: N/A
• First received: July 21, 2016
• Last updated: July 25, 2016
• Start date: May 2014
• Est. completion date: April 2015

Study information

• Verified date: July 2016
• Source: Kirikkale University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ethics Committee
• Study type: Observational

Clinical Trial Summary

This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health. 25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included into this study. In each participant, four sites are identified for gingival crevicular fluid samples.

Description:

Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage.

Advanced oxidation protein product is identified as a new marker of protein oxidation.

Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 75
• Est. completion date: April 2015
• Est. primary completion date: January 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 66 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of chronic periodontitis and gingivitis

Exclusion Criteria:

• Systemic illnesses

• Any medications known to affect the periodontium

• Pregnancy and lactation

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Gingival Diseases
• Inflammation
• Periodontal Disease
• Periodontal Diseases

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Kirikkale University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Advanced oxidation protein product (nmol)		Before periodontal treatment	No
Secondary	Monocyte chemoattractant protein-1(pg)		Before periodontal treatment	No
Secondary	The probing depth (mm), clinical attachment level (mm), plaque index scores (0-3) and gingival index scores (0-3)		Before periodontal treatment	No