Inflammation Clinical Trial
Official title:
Pulmonary Effects of 100% Biodiesel Exhaust
Air pollution is a global environmental and health concern, contributing to onset and
deterioration of respiratory and cardiovascular diseases. As climate change and dependence
on diminishing fossil fuel supplies have taken center stage in political and scientific
debates, renewable carbon-neutral fuels like biodiesel receive increasing attention. The
most common biodiesel within the European Union, rapeseed oil methyl ester (RME) is
perceived to be a "green fuel", as it is sustainable and of biological origin, and therefore
is often predicted to be less harmful to human health. Whilst replacing petrodiesel with
biodiesel may have advantageous ecological impacts, consequences to respiratory health
remained largely unexplored.
The purpose of the current study is to evaluate whether inhalation of 100% RME biodiesel
exhaust would result in an acute airway inflammatory response in healthy human subjects, as
shown previously following exposure to petrodiesel exhaust.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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