Inflammation Clinical Trial
Official title:
Mängden kvävgasbubblor i Blodet Efter Dykning Vid Syrgasandning jämfört Med Luftandning
Verified date | May 2022 |
Source | Göteborg University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Primary objective: - Assessment of venous gas emboli load post diving when breathing normobaric oxygen compared to air. Secondary objective: - Assessment of fluid markers of central nervous system injury in blood post diving - Assessment of fluid markers of inflammation and endothelial dysfunction in blood post diving Tertiary objective: - Assessment of DCS frequency
Status | Completed |
Enrollment | 48 |
Est. completion date | April 2019 |
Est. primary completion date | April 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Professional diver - Fit to dive according to Swedish Navy standards Exclusion Criteria: - NONE |
Country | Name | City | State |
---|---|---|---|
Sweden | Sahlgrenska University Hospital | Gothenburg | |
Sweden | Kungliga Tekniska Högskolan | Stockholm |
Lead Sponsor | Collaborator |
---|---|
Göteborg University | KTH Royal Institute of Technology, Sahlgrenska University Hospital, Sweden, Swedish Armed Forces Diving and Naval Medicine Centre |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Venous gas emboli | Kisman-Masurel grading | 120 minutes | |
Secondary | Inflammatory activity and endothelial dysfunction | E.g. VCAM-1, ICAM-1 | 120 minutes/ 48 hours | |
Secondary | Decompression sickness | Clinical diagnosis | 24 hours | |
Secondary | Markers of central nervous system injury | E.g. GFAP, Tau, NfL, UCHL-1 | 120 minutes/ 48 hours |
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