Inflammation Clinical Trial
Official title:
A Single Site Double Blind Placebo Controlled Study of the Effects of a Dietary Supplement on Muscle Recovery Following Exercise-Induced Muscle Damage
The objectives of this study are to assess the effectiveness of a nutritional supplement on muscle functional recovery following induced muscle damage from high intensity resistance exercise. The investigators hypothesize that a short-term dietary supplementation will significantly improve muscle functional recovery following an intense bout of eccentric exercise compared to a placebo.
Impaired or incomplete recovery following high intensity exercise can negatively affect
physical performance and delay functional progression, thereby reducing an athlete's chance
of performing at his or her peak level. Athletes are constantly seeking ways to speed muscle
recovery from strenuous exercise and muscle damage. Anabolic steroids are potent stimulators
of muscle growth and repair and have been used extensively by athletes to hasten structural
and functional recovery during peak periods of strenuous training. However, anabolic steroids
are classified as banned substances by all major sports organizing committees that oversee
and regulate amateur and professional athletics. In addition long-term use of anabolic
steroids has known side effects that can negatively impact an athlete's health status.
Dietary supplements are safe and viable alternatives that, if taken in the optimal doses, can
provide positive effects on muscle growth and repair and ultimately human performance.
Athletes have used dietary supplements extensively to facilitate tissue growth and repair
following muscle-damaging events such as high-intensity resistance exercise and participation
in contact sports. Following intense resistance exercise, an acute inflammatory response
drives the repair process by synthesizing and releasing chemical mediators locally in the
injured muscle. Inflammatory mediators help attract growth factors used for protein
synthesis. The inflammatory response has also been shown to produce high levels of
oxygen-derived free radicals that if allowed to proceed unabated, can produce further muscle
damage, thus hindering the repair process. A protein-based dietary supplement, if taken in
the optimal dosing schedule, may enhance the recovery process by blunting the magnitude of
the acute inflammatory response and facilitating growth and repair through increased protein
synthesis in damaged muscle tissue. Understanding the nutritional requirements of athletes
engaged in high intensity training and competition is necessary to insure adequate recovery
between exercise bouts. This will improve training and functional gains as well as act as a
prophylaxis to skeletal muscle injury.
The objectives of this study are to assess the effectiveness of a nutritional supplement on
muscle functional recovery following induced muscle damage from high intensity resistance
exercise. This will be accomplished by evaluating baseline changes over the course of the
recovery phase on severity of the symptomatic response and functional impairment in
post-exercise skeletal muscle damage. The biceps brachii muscle will be targeted for this
study. The investigators have established a safe and effective experimental arm curl model
for inducing skeletal muscle soreness and dysfunction in human subjects using eccentric
exercise to the bicep brachii muscle.
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