Inflammatory Markers in Sputum After LPS Inhalation

Status Active, not recruiting

Clinical Trial Summary

The purpose of the study is to measure inflammatory biomarkers in sputum and peripheral blood in healthy volunteers after inhalation of single doses of LPS (20 mcg) administered as particles of different sizes.

Clinical Trial Description

Endotoxins are inflammatory substances present in the environment. In man, the inhalation of the lipopolysaccharride moiety (LPS) induces measurable immune responses. With an inhaled single dose of 20 micron, the inflammatory response in man is sub-clinical. During bronchoprovocation tests with allergens, the particle size determines to a large extent the intensity of the response. the response to LPS as a function of particle size is not known and will be studied in this study. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Inflammation

Clinical Trial Details

NCT number	NCT01081392
Study type	Interventional
Source	Centre Hospitalier Universitaire Brugmann
Contact
Status	Active, not recruiting
Phase	N/A
Start date	January 2010
Completion date	May 2010

View Details

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