Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation

Inflammation Clinical Trial

Official title:

Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00847743
• Other study ID #: KLRI-2007-03
• Status: Completed
• Phase: N/A
• First received: February 17, 2009
• Last updated: February 18, 2009
• Start date: October 2007
• Est. completion date: April 2008

Study information

• Verified date: February 2009
• Source: Kronos Longevity Research Institute
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation.

Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives.

We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.

Description:

Objectives

The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: April 2008
• Est. primary completion date: April 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 55 Years to 80 Years

Eligibility

Inclusion Criteria:

• men and women, ages 55-80y, in good health, with >8 years of education

• non-smoker

• able to give informed consent

Exclusion Criteria:

• use of anti-oxidant supplements, in excess of a standard multi-vitamins

• current hormone replacement therapy

• any history of significant chronic disease

• uncontrolled hypertension

• body mass index (BMI) > 30 kg/m2

• high physical activity level, as determined by questions on the screening questionnaire

• use of anti-inflammatory medication

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Antioxidant Capacity
• Inflammation
• Oxidative Stress

Intervention

Dietary Supplement:
• Tart Cherry Juice
8 fl.oz. twice per day

Locations

Country	Name	City	State
United States	Kronos Longevity Research Institute	Phoenix	Arizona

Sponsors (2)

Lead Sponsor	Collaborator
Kronos Longevity Research Institute	Vanderbilt University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge.			No
Secondary	Urinary markers of oxidative damage.			No