Metabolic Study of Concentric and Eccentric Muscle Training

Inflammation Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00386854
• Other study ID #: K01-2003-1
• Status: Completed
• Phase: N/A
• First received: October 10, 2006
• Last updated: October 10, 2006
• Start date: April 2003
• Est. completion date: August 2003

Study information

• Verified date: October 2006
• Source: Vorarlberg Institute for Vascular Investigation and Treatment
• Contact: n/a
• Is FDA regulated: No
• Health authority: Austria: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

Description:

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.

Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: August 2003
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 30 Years and older

Eligibility

Inclusion Criteria:

• healthy men and women

• age over 30 years

Exclusion Criteria:

• previous systematic endurance training (=3 times per week =30 min)

• body mass index >30 kg/m2

• heavy smoking (>20 cigarettes per day)

• regular alcohol consumption >60g per day

• established musculoskeletal disease

• history of cardiovascular disease

• diabetes mellitus

• unwillingness to stay in the area for the whole study period

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Educational/Counseling/Training

Related Conditions & MeSH terms

• Inflammation
• Insulin Resistance
• Lipid Metabolism

Intervention

Behavioral:
• physical training

Locations

Country	Name	City	State
Austria	Vorarlberg Institute of Vascular Investigation and Treatment	Feldkirch	Vorarlberg

Sponsors (1)

Lead Sponsor	Collaborator
Vorarlberg Institute for Vascular Investigation and Treatment

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.
Secondary	Metabolic and anti-inflammatory effects induced by concentric muscle exercise.