Adding Insulin to IVF Culture Media Significantly Improve Outcome

Infertility Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02420171
• Other study ID #: Ibnsina IVF center Sohag
• Status: Completed
• Phase: N/A
• First received: April 14, 2015
• Last updated: July 11, 2016
• Start date: January 2015
• Est. completion date: December 2015

Study information

• Verified date: July 2016
• Source: Ibn Sina Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Egypt: Banon IVF center
• Study type: Interventional

Clinical Trial Summary

Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In Vitro culture and detect the the effect upon embryo quality and implantation potential.

Description:

The IVF culture media design and upgrade underwent many ideas during the last 3 decades, we suppose that adding insulin as a hormon and growth factor might improve embryo development in vitro so we decide to design a trial to compare the embryogenesis by sibling Oocytes of the same patient between to arm of the same culture media and yhe same culture condition but with one arm with insulin and the other is traditional one and closely monitor the outcome within the 2 arms abd record the results

Recruitment information / eligibility

• Status: Completed
• Enrollment: 360
• Est. completion date: December 2015
• Est. primary completion date: December 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• normal responder

• PCOS

• Tubal factor infertility

• mild asthenozoospermia

Exclusion Criteria:

• patient over 40

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Infertility

Intervention

Other:
• Adding insulin to In Vitro culture media
We will add insulin for in vitro culture of human embryos

Locations

Country	Name	City	State
Egypt	Banon IVF Center	Assiut
Egypt	Ibnsina IVF center	Sohag

Sponsors (2)

Lead Sponsor	Collaborator
Ibn Sina Hospital	Banon IVF Center Assiut, Egypt

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	clinical Pregnancy rate ( % )		6 months	Yes
Secondary	Blastocyst rate ( % )		6 months	Yes
Secondary	Blastocyst quality rate ( % )		6 months	Yes