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A Pilot Study Analyzing Reproductive Results After IUI Using Vitrified Human Sperm — BIOKIBANK  

Infertility Clinical Trial

Official title:
Analysis of Reproductive Outcomes Obtained in Patients Undergoing Intrauterine Insemination With Donor Sperm Previously Vitrified - Pilot Study

Clinical Trial Summary

The aim of this study is to assess the evaluate the effectiveness of vitrified donor semen in intrauterine insemination treatments.

Clinical Trial Description

Sperm cryopreservation is an efficient procedure widely used in fertility clinics, that provides logistical flexibility and increases the potential for success in assisted reproduction. It has been demonstrated that reproductive rates are comparable when using frozen sperm or fresh semen. However, sperm freezing using standard protocols is inevitably associated with a loss of motility, membrane integrity, and other post-thaw sperm quality parameters due to what is known as cryodamage, which involves the formation of intracellular ice crystals, osmotic shock, and dehydration. Sperm vitrification has been recently developed as an improved alternative, where freezing occurs extremely rapidly (-20,000 ºC/min). Consequently, the formation of intracellular ice crystals is reduced, leading to improvements in sperm motility, vitality, and integrity. However, the use of vitrified semen in fertility clinics is scarce, and no study has addressed whether vitrification could affect reproductive outcomes, such as live birth. The aim of this study is to assess the evaluate the effectiveness of vitrified donor semen in intrauterine insemination treatments through the analysis of clinical pregnancy (primary objective) and as secondary objectives the number of progressive sperm post-thaw, percentage of progressive sperm and biochemical pregnancy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06243913
Study type Observational
Source Clínica EUGIN
Contact Mina Popovic, PhD
Phone 933221122
Email investigacion@eugin.es
Status Recruiting
Phase
Start date December 20, 2022
Completion date December 2025
View Details
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